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Receptor, Cannabinoid, CB1

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Definition: A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.      Other names Receptor, CB1; Receptor CB1, Cannabinoid; CB1 Receptor; Cannabinoid Receptor CB1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CNR1 protein, human  0   *Receptor, Cannabinoid, CB1. Gene. 2012 Mar 10;495(2):194-8
1,3-dihydroxypropan-2-yl 11-(3-hydroxy-5-(2-methyloctan-2-yl)phenoxy)undecanoate  0   *Monoglycerides Ligands Receptor, Cannabinoid, CB1. J Med Chem. 2011 Dec 22;54(24):8278-88.
1,3-dihydroxypropan-2-yl 11-(2-hexyl-5-hydroxyphenoxy)undecanoate  0   *Phenols *Monoglycerides Ligands Receptor, Cannabinoid, CB1. J Med Chem. 2011 Dec 22;54(24):8278-88.
N-cyclohexyl-4-(1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl)piperazine-1-carboxamide  0   *Piperazines Receptor, Cannabinoid, CB1/antagonists & inhibitors. Eur J Med Chem. 2010 Mar;45(3):1133-9.
3-(4-chlorophenyl)-N-((4-chlorophenyl)sulfonyl)-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide  0   *Amidines *Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Pharm Sci. 2011 Nov;100(11):4687-99.
(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)(piperidin-1-yl)methanone  0   *Piperidines *Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Acta Pharmacol Sin. 2011 Sep;32(9):1148-58.
sesquicannabigerol  0   *Cannabinoids Receptor, Cannabinoid, CB1/drug effects Receptor, Cannabinoid, CB2/drug effects. J Nat Prod. 2011 Sep 23;74(9):2019-22
2-(5-(4-bromophenyl)-1-(2-chlorophenyl)-4-(methylsulfonyl)-1H-pyrazol-3-yl)-5-(1-(trifluoromethyl)cyclobutyl)-1,3,4-thiadiazole  0   *Pyrazoles *Thiadiazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Future Med Chem 2009 Aug;1(5):947-67
2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(methylsulfonyl)-1H-pyrazol-3-yl)-5-(1-(trifluoromethyl)cyclobutyl)-1,3,4-thiadiazole  0   *Pyrazoles *Thiadiazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Future Med Chem 2009 Aug;1(5):947-67
3-(1-(1-((4-chlorophenyl)(3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl)methyl)azetidin-3-yl)-2-fluoro-2-methylpropyl)-5-fluorobenzonitrile  0   *Azetidines *Oxadiazoles Receptor, Cannabinoid, CB1. Behav Pharmacol 2011 Apr;22(2):91-100
LY2190416  0   *Indoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Vet Pharmacol Ther. 2010 Dec;33(6):615-8
N-(1-(cyclohexylmethyl)-2-((5-ethoxypyridin-2-yl)methyl)-1H-benzo(d)imidazol-5-yl)-N-methylthiophene-2-sulfonamide  0   *Benzimidazoles *Sulfonamides Receptor, Cannabinoid, CB1/agonists. Pain 2010 Nov;151(2):337-44
1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide  0   *Pyrazoles *Thiophenes Receptor, Cannabinoid, CB1/agonists. ChemMedChem 2010 Sep 3;5(9):1439-43
N-(3-((3-aminopropyl)amino)propyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide  0   *Pyrazoles Ligands Receptor, Cannabinoid, CB1. J Med Chem 2010 Oct 14;53(19):7048-60
N,N'-(iminodiheptane-7,1-diyl)bis(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide)  0   *Pyrazoles Ligands Receptor, Cannabinoid, CB1. J Med Chem 2010 Oct 14;53(19):7048-60
3-(1-hexylcyclobut-1-yl)-6a,7,8,9,10,10a-hexahydro-6,6-dimethyl-6H-dibenzo(b,d)pyran-1,9 diol  0   *Benzopyrans Receptor, Cannabinoid, CB1/agonists. J Med Chem 2010 Oct 14;53(19):6996-7010
N-(3-chlorobenzyl)-3-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)acrylamide  0   *Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Int J Obes (Lond) 2010 Mar;34(3):547-56
1-(7-(2-chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo(1,5-a)(1,3,5)triazin-4-yl)-3-(methylamino)azetidine-3-carboxamide  0   *Azetidines *Triazines Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Oct;335(1):103-13
1-pentyl-3-(1-naphthoyl)indole  0   *Indoles *Naphthalenes Ligands Street Drugs Receptor, Cannabinoid, CB1. Pediatr Emerg Care. 2010 Jun;26(6):462-5
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(pyridin-3-methyl)-1H-pyrazole-3-carboxamide  0   *Pyrazoles *Pyridines Receptor, Cannabinoid, CB1. Eur J Pharmacol 2010 Jul 10;637(1-3):178-85
AM6545  0   *Morpholines *Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Clin Invest. 2010 Aug 2;120(8):2953-66
18-(5-methyl-2,5-diazabicyclo(2.2.1)heptan-2-yl)-18-oxooctadec-9-en-7-yl phenylacetate  0   *Oleic Acids *Azabicyclo Compounds Receptor, Cannabinoid, CB1/agonists. Bioorg Med Chem Lett 2010 Jun 1;20(11):3231-4
SLV 330  0   *Pyrazoles *Sulfonamides Receptor, Cannabinoid, CB1/antagonists & inhibitors. Neurobiol Learn Mem 2010 May;93(4):522-31
N-(6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano(2,3-b)pyridin-4-yl)-5-methyl-1H-pyrazole-3-carboxamide  0   *Pyrans *Pyridines Receptor, Cannabinoid, CB1/agonists. J Med Chem 2010 May 27;53(10):4028-37
Cnr1 protein, rat  0   *Receptor, Cannabinoid, CB1.
2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo(3,4-f)(1,4)oxazepin-8(5H)-one  0   *Oxazepines Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Med Chem 2009 May 14;52(9):2652-5
8-(5-(2-Methyloctan-2-yl)phenoxy)octanoic acid cyclopropylamide  0   *Phenols Ligands Receptor, Cannabinoid, CB1. J Med Chem 2009 Apr 23;52(8):2506-14
11-(3-chloro-4-fluorophenyl)dibenzo(b,f)(1,4)thiazepine-8-carboxylic acid butylamide  0   *Thiazepines Receptor, Cannabinoid, CB1/agonists. J Med Chem 2009 Apr 9;52(7):1975-82
AM 6527  0   *Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Pharmacol Biochem Behav 2009 Jan;91(3):303-6
1-(9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl)-4-ethylaminopiperidine-4-carboxylic acid amide  0   *Piperidines *Purines Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Med Chem 2009 Jan 22;52(2):234-7
(2-(2,4-dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)benzo(1,3)dioxol-5-yl)morpholin-4-ylmethanone  0   *Benzodioxoles Receptor, Cannabinoid, CB1/agonists. J Med Chem 2008 Apr 10;51(7):2115-27
1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea  0   *Phenylurea Compounds *Pyridines Receptor, Cannabinoid, CB1/antagonists & inhibitors. Br J Pharmacol 2007 Nov;152(5):805-14
naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone  0   *Naphthalenes Receptor, Cannabinoid, CB1/agonists Receptor, Cannabinoid, CB2/agonists. J Med Chem 2007 Aug 9;50(16):3851-6
1,3-bis(4-bromophenyl)-5-phenylimidazolidine-2,4-dione  0   *Imidazolidines Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Med Chem 2006 Feb 9;49(3):872-82
1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methyl-N-(piperidin-1-yl)-1H-imidazole-4-carboxamide  0   *Imidazoles *Piperidines Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):1823-38
O 1812  0   *Arachidonic Acids Receptor, Cannabinoid, CB1/antagonists & inhibitors. Exp Clin Psychopharmacol. 2004 Aug;12(3):173-9
(-)-adamantyl-delta8-tetrahydrocannabinol  0   Adamantane/*analogs & derivatives Tetrahydrocannabinol/*analogs & derivatives Receptor, Cannabinoid, CB1/agonists. Behav Pharmacol. 2004 Nov;15(7):517-21
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide  0   *Pyrazoles *Piperidines Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Pharmacol Exp Ther 2004 Sep;310(3):845-54
3-(4-chlorophenyl)-N-methyl-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine  0   *Pyrazoles *Sulfonamides Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Med Chem 2004 Jan 29;47(3):627-43

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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