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Receptor, Cannabinoid, CB2

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Definition: A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.  see SCR for organism-specific terms    Other names Receptor, CB2; Receptor CB2, Cannabinoid; CB2, Cannabinoid Receptor; CB2 Receptor; Cannabinoid Receptor CB2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
O-1996A  0   *Anisoles Receptor, Cannabinoid, CB2/agonists. J Pharmacol Exp Ther. 2002 May;301(2):679-89.
N-(1-(4-((4-chloro-2-((2-fluorophenyl)sulfonyl)phenyl)sulfonyl)phenyl)ethyl)methanesulfonamide  0   *Sulfonamides *Sulfones Receptor, Cannabinoid, CB2/antagonists & inhibitors. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3534-9.
Cnr2 protein, mouse  0   *Receptor, Cannabinoid, CB2. Am J Physiol Heart Circ Physiol. 2012 Mar;302(5):H1064-74
3-cyclopropyl-1-(4-(6-(1,1-dioxo-1gamma6-thiomorpholin-4-ylmethyl)-5-fluoro-pyridin-2-yl)benzyl)imidazolidine-2,4-dione  0   *Cyclic S-Oxides *Hydantoins Receptor, Cannabinoid, CB2/agonists. J Med Chem. 2011 Oct 27;54(20):7350-62.
O 3223  0   Tetrahydrocannabinol/*analogs & derivatives Receptor, Cannabinoid, CB2/agonists. Neuropharmacology 2011 Feb-Mar;60(2-3):244-51
sesquicannabigerol  0   *Cannabinoids Receptor, Cannabinoid, CB1/drug effects Receptor, Cannabinoid, CB2/drug effects. J Nat Prod. 2011 Sep 23;74(9):2019-22
N-(adamantan-1-yl)-8-methoxy-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide  0   *Quinolones Adamantane/*analogs & derivatives Ligands Receptor, Cannabinoid, CB2. J Med Chem 2011 Aug 11;54(15):5444-53
1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid morpholineamide  0   *Indoleacetic Acids *Morpholines Receptor, Cannabinoid, CB2/agonists. Prostaglandins Other Lipid Mediat 2011 Feb;94(1-2):17-24
N-(morpholinyl)-1-(3-(trifluoromethyl)phenylamino)isoquinoline-4-carboxamide  0   *Isoquinolines *Morpholines Receptor, Cannabinoid, CB2/agonists. Bioorg Med Chem. 2011 Jan 15;19(2):939-50
1-bromo-1-deoxy-3-(1',1'-dimethylhexyl)-delta(8)-tetrahydrocannabinol  0   Tetrahydrocannabinol/*analogs & derivatives Ligands Receptor, Cannabinoid, CB2. Bioorg Med Chem 2010 Nov 15;18(22):7809-15
N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide  0   *Indenes *Pyrazoles Receptor, Cannabinoid, CB2/agonists. J Neuroimmune Pharmacol 2010 Sep;5(3):456-68
N'-((3Z)-1-(1-hexyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide  0   *Hydrazines *Indoles Receptor, Cannabinoid, CB2/agonists. Anesth Analg. 2010 Jul;111(1):99-109
N-(3,4-dimethyl-5-(morpholinosulfonyl)phenyl)-2,2-dimethylbutanamide  0   *Aniline Compounds *Sulfonamides Receptor, Cannabinoid, CB2/agonists. Bioorg Med Chem Lett 2010 Jan 1;20(1):387-91
1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno(1,2-c)pyrazole-3 carboxamide  0   *Indenes *Pyrazoles Receptor, Cannabinoid, CB2/agonists. Neurobiol Dis 2010 Jan;37(1):177-85
2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide  0   *Aminopyridines *Morpholines Receptor, Cannabinoid, CB2/agonists. Bioorg Med Chem Lett 2009 Oct 15;19(20):5931-5
1-(4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo(3,2-c)pyridin-7-yl)-1-morpholin-4-ylmethanone  0   *Aminopyridines *Morpholines Receptor, Cannabinoid, CB2/agonists. J Med Chem 2009 Oct 8;52(19):5785-8
A-836339  0   *Thiazoles Receptor, Cannabinoid, CB2/agonists. Neuroscience 2009 Feb 18;158(4):1652-61
1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine  0   *Benzofurans *Piperidines Receptor, Cannabinoid, CB2/agonists. Br J Pharmacol 2008 Dec;155(7):1104-16
6-chloro-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propyl)quinolin-3-amine  0   *Aminoquinolines *Oxadiazoles Receptor, Cannabinoid, CB2/agonists. J Med Chem 2008 Aug 28;51(16):5019-34
naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone  0   *Naphthalenes Receptor, Cannabinoid, CB1/agonists Receptor, Cannabinoid, CB2/agonists. J Med Chem 2007 Aug 9;50(16):3851-6
2-((2,4-dichlorphenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide  0   *Pyrans *Pyrimidines Receptor, Cannabinoid, CB2/agonists. J Med Chem 2007 May 31;50(11):2597-600
1-isoquinolyl-(3-(trifluoromethyl)phenyl)methanone  0   *Isoquinolines Receptor, Cannabinoid, CB2/agonists. J Med Chem 2005 Nov 17;48(23):7166-71
Cnr2 protein, rat  0   *Receptor, Cannabinoid, CB2.
AM 1241  0   Cannabinoids Analgesics Receptor, Cannabinoid, CB2. Pain 2001 Sep;93(3):239-45
anandamide  94421-68-8 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)  *Arachidonic Acids *Polyunsaturated Alkamides Cannabinoids Receptor, Cannabinoid, CB2.
Pharma Action Calcium Channel Blockers ; Endocannabinoids 		Science 1992 Dec 18;258(5090):1882-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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