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Receptors, Formyl Peptide

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Definition: A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.      Other names fMet Leu Phe Receptor; Receptor, fMet-Leu-Phe; Receptor, N-formyl Hexapeptide; Receptor, N-Formylmethionyl Peptide; Receptor, Formyl Peptide; Receptor, FMLP; Receptor, F-Chemotactic Peptide; Receptor, Chemoattractant; Peptide Receptors, Formyl; Peptide Receptor, N-Formylmethionyl; Peptide Receptor, Chemotactic; N formyl Hexapeptide Receptor; N Formylmethionyl Peptide Receptor; Hexapeptide Receptor, N-formyl; Formyl Peptide Receptors; F Chemotactic Peptide Receptor; fMet-Leu-Phe Receptor; Receptor, Chemotactic Peptide; N-formyl Hexapeptide Receptor; N-Formylmethionyl Peptide Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Fpr-rs8 protein, mouse  0   *Receptors, Formyl Peptide. J Innate Immun. 2011;3(5):519-29.
hederagenin 3-O-(3,4-O-diacetylarabinopyranoside)-1-3-rhamnopyranosyl-1-2-arabinopyranoside  0   *Saponins Receptors, Formyl Peptide/antagonists & inhibitors. Biochem Pharmacol 2010 Oct 15;80(8):1190-200
formyl peptide receptor 2, mouse  0   *Receptors, Formyl Peptide. J Immunol. 2003 Nov 15;171(10):5482-8
Fpr-rs2 protein, mouse  0   *Receptors, Formyl Peptide.
Fprl1 protein, mouse  0   *Receptors, Formyl Peptide.
Fpr-rs1 protein, mouse  0   *Receptors, Formyl Peptide.
Fpr1 protein, mouse  0   *Receptors, Formyl Peptide.
FPR1 protein, human  0   *Receptors, Formyl Peptide.
FPR3 protein, human  0   *Receptors, Formyl Peptide.
FPR2 protein, human  0   *Receptors, Formyl Peptide *Receptors, Lipoxin Eicosanoids. Adv Exp Med Biol 1999;447:133-49; J Biol Chem 1997 Mar 14;272(11):6972-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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