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Receptor, Angiotensin, Type 1

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Definition: An angiotensin receptor subtype that is expressed at high levels in a variety of adult tissues including the CARDIOVASCULAR SYSTEM, the KIDNEY, the ENDOCRINE SYSTEM and the NERVOUS SYSTEM. Activation of the type 1 angiotensin receptor causes VASOCONSTRICTION and sodium retention.      Other names Receptor, Angiotensin AT1b; Receptor, Angiotensin AT1a; Receptor, Angiotensin AT1; AT1b Receptor, Angiotensin; AT1a Receptor, Angiotensin; AT1 Receptor, Angiotensin; Receptor, Angiotensin II Type 1b; Receptor, Angiotensin II Type 1a; Receptor, Angiotensin II Type 1; Angiotensin II Type 1b Receptor; Angiotensin II Type 1a Receptor; Angiotensin AT1b Receptor; Angiotensin AT1a Receptor; Angiotensin AT1 Receptor; Receptor, Angiotensin, Type 1b; Receptor, Angiotensin, Type 1a; Angiotensin Type 1b Receptor; Angiotensin Type 1a Receptor; Angiotensin Type 1 Receptor; Angiotensin II Type 1 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-pentanoyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pyrrolidine-2-carboxamide  0   Losartan/*analogs & derivatives Ligands Receptor, Angiotensin, Type 1. ChemMedChem. 2007 Sep;2(9):1298-310.
Agtr1a protein, rat  0   *Receptor, Angiotensin, Type 1.
Agtr1a protein, mouse  0   *Receptor, Angiotensin, Type 1.
AGTR1 protein, human  0   *Receptor, Angiotensin, Type 1.
2-butyl-4-chloro-5-formyl-1-((3-(2-methoxyphenyl)isoxazolyl-5-methyl))imidazole  0   *Imidazoles *Isoxazoles Receptor, Angiotensin, Type 1. Yao Xue Xue Bao 2007 Aug;42(8):822-7
5-n-butyl-4-(4-(2-(1H-tetrazol-5-yl)-1H-pyrrol-1-yl)phenylmethyl)-2,4-dihydro-2-(2,6-dichlorophenyl)-3H-1,2,4-triazol-3-one  0   *Tetrazoles *Triazoles Receptor, Angiotensin, Type 1. Biomed Chromatogr 2007 Sep;21(9):912-24
V8 compound  0   Losartan/*analogs & derivatives Receptor, Angiotensin, Type 1. J Pharm Biomed Anal 2006 Mar 18;40(5):1097-104
4'-((2-butyl-4-oxo-1,3-diazaspiro(4.4)non-1-en-3-yl)methyl)-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)(1,1'-biphenyl)-2-sulfonamide  0   *Isoxazoles *Sulfonamides Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Med Chem 2005 Jan 13;48(1):171-9
3-((2'-(benzoylaminosulfonyl)(1,1'-biphenyl)-4-yl)methyl)-2-butyl-2,3-diazaspiro(4.4)nonane-1,4-dione  0   *Pyrazoles *Spiro Compounds Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Med Chem 2000 Jul 13;43(14):2685-97
2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-2,3-diazaspiro(4.4)nonane-1,4-dione  0   *Pyrazoles *Spiro Compounds Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Med Chem 2000 Jul 13;43(14):2685-97
UR 7247  0   *Pyrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Cardiovasc Pharmacol 2000 Mar;35(3):383-9
GA 0113  0   *Quinolines *Sulfonamides Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Cardiovasc Pharmacol 1999 Oct;34(4):526-32
2-(((2-butyl-1-((4-carboxyphenyl)-methyl)-1H-imidazol-5-yl)methyl)amino)-4-azidobenzoic acid  0   *Azides *Benzoic Acids Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4572-83
KD3 671  0   *Imidazoles *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. Eur J Pharmacol 1999 Jun 11;374(1):93-101
57G709  0   *Imidazoles *Pyridines Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Lab Clin Med 1999 Feb;133(2):134-43
KR 31080  0   *Pyridines *Tetrazoles Angiotensin II Receptor, Angiotensin, Type 1/antagonists & inhibitors. Fundam Clin Pharmacol 1998;12(1):64-9
CL 329167  0   *Tetrazoles *Quinazolinones Receptor, Angiotensin, Type 1. Clin Exp Hypertens 1997 Nov;19(8):1247-61
TH 142177  0   *Tetrazoles Glycine/*analogs & derivatives Receptor, Angiotensin, Type 1/antagonists & inhibitors. Fundam Clin Pharmacol 1997;11(5):395-401
embusartan  156001-18-2   *Dihydropyridines *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors Angiotensin II Type 1 Receptor Blockers. Arzneimittelforschung 1997 Sep;47(9):1016-23
KRH 594  0   *Tetrazoles *Thiadiazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. Biol Pharm Bull 1997 Aug;20(8):850-5
606A compound  0   *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Cardiovasc Pharmacol 1997 Feb;29(2):284-90
UR 7280  0   *Pyrazoles *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. Eur J Pharmacol 1996 Dec 30;218(2-3):341-7
YM358  0   *Azoles *Biphenyl Compounds Receptor, Angiotensin, Type 1/antagonists & inhibitors. Jpn J Pharmacol 1997 Jan;73(1):83-91
BMS 183920  153072-33-4   *Quinolines *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. J Pharm Sci 1996 Aug;85(8):828-33
HN 65021  0   *Imidazoles *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. Br J Clin Pharmacol 1995 Dec;40(6):591-3
LR B-081  0   *Pyrimidinones *Thiophenes Receptor, Angiotensin, Type 1/antagonists & inhibitors. Br J Pharmacol 1995 Mar;114(6):1117-24
E 4177  135070-05-2   *Imidazoles *Pyridines Receptor, Angiotensin, Type 1/antagonists & inhibitors. Jpn J Pharmacol 1993 Jul;62(3):239-44
GR 117289  145781-32-4   *Nicotinic Acids *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors. Br J Pharmacol 1992 Dec;107(4):1173-80

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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