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Receptors, Calcium-Sensing

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Definition: A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.  CALCIUM-BINDING PROTEINS is also available   
See Also Intracellular Calcium-Sensing Proteins 		Other names Receptors, Calcium Sensing; Receptors, Ca-Sensing; Receptor, Parathyroid Calcium-Sensing; Receptor, Calcium-Sensing; Receptor, Ca2+-Sensing; Receptor, Ca Sensing; Receptor Protein, Calcium-Sensing; Parathyroid Calcium Sensing Receptor; Extracellular Calcium Ion Sensing Receptor; Calcium-Sensing Receptor, Parathyroid; Calcium Sensing Receptors; Calcium Sensing Receptor Protein; Calcium Sensing Receptor; Ca2+ Sensing Receptor; Ca-Sensing Receptor; Ca Sensing Receptors; Receptors, Calcium; Receptor, Ca-Sensing; Parathyroid Calcium-Sensing Receptor; Extracellular Calcium-Ion Sensing Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-quinoxaline-carboxamide-N-adamantan-1-yl  0   *Quinoxalines Adamantane/*analogs & derivatives Receptors, Calcium-Sensing/antagonists & inhibitors. Mol Pharmacol. 2003 May;63(5):1082-93.
N-(1-ethyl-1-(4-ethylphenyl)propyl)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide  0   *Pyrazoles *Pyrimidines Receptors, Calcium-Sensing/antagonists & inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):1881-94
N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide  0   *Pyrazoles *Pyrimidines Receptors, Calcium-Sensing/antagonists & inhibitors. J Med Chem 2011 Mar 10;54(5):1430-40
3-(3-cyano-4-((3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropyl)oxy)phenyl)propanoic Acid  0   *Phenylpropionates *Propanolamines Receptors, Calcium-Sensing/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6599-605
extracellular calcium cation-sensing receptor, rat  0   *Receptors, Calcium-Sensing. Proc Natl Acad Sci U S A 1995 Jan 3;92(1):131-5; RefSeq NM_016996
CASR protein, human  0   *Receptors, Calcium-Sensing Calcium Signaling. Biochem Biophys Res Commun 1995 Sep 14;214(2):524-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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