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Receptor, Serotonin, 5-HT1A

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Definition: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.      Other names Serotonin, 5 HT1a Receptor; Serotonin Receptor, 5 HT1A; Receptors, 5-Hydroxytryptamine 1A; Receptor, Serotonin 1A; Receptor, 5-HT1A Serotonin; Receptor, 5-HT1A; Receptor, 5 Hydroxytryptamine 1A; Receptor Serotonin, 5-HT1a; 5-HT1a Receptor Serotonin; 5-HT1A Serotonin Receptor; 5 Hydroxytryptamine 1A Receptors; 5 Hydroxytryptamine 1A Receptor; 5 HT1A Receptor; 1A Receptors, 5-Hydroxytryptamine; 1A Receptor, Serotonin; 1A Receptor, 5-Hydroxytryptamine; Serotonin, 5-HT1a Receptor; Serotonin Receptor, 5-HT1A; Receptor, 5-Hydroxytryptamine 1A; 5-Hydroxytryptamine 1A Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-2,2-diphenylcyclopentan-1-ol  0   *Cyclopentanes *Piperazines Serotonin Antagonists Receptor, Serotonin, 5-HT1A. J Med Chem. 2012 Jan 12;55(1):23-36.
((5,5-diphenyloxolan-2-yl)methyl)(2-phenoxyethyl)amine  0   *Furans Serotonin Antagonists Receptor, Serotonin, 5-HT1A. J Med Chem. 2012 Jan 12;55(1):23-36.
2-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione  0   *Benzopyrans *Bicyclo Compounds, Heterocyclic Receptor, Serotonin, 5-HT1A Serotonin 5-HT1 Receptor Agonists. J Med Chem. 2011 Dec 8;54(23):7986-99.
Lu AA21004  0   *Piperazines *Sulfides Receptor, Serotonin, 5-HT1A Receptors, Serotonin, 5-HT3. IDrugs 2010 Dec;13(12):900-10
6-(2-(4-(2-methyl-5-quinolinyl)-1-piperazinyl)ethyl)-4H-imidazo(5,1-c)(1,4)benzoxazine-3-carboxamide  0   *Benzoxazines Receptor, Serotonin, 5-HT1A Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D. J Med Chem 2010 Aug 12;53(15):5827-43
N'-cyano-N-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)isonicotinamidine  0   *Amidines Niacinamide/*analogs & derivatives Ligands Receptor, Serotonin, 5-HT1A. Bioorg Med Chem Lett 2010 May 1;20(9):2978-82
5-fluoro-8-(4-(4-(6-methoxyquinolin-8-yl)piperazin-1-yl)piperidin-1-yl)quinoline  0   *Piperazines *Quinolines Receptor, Serotonin, 5-HT1A/antagonists & inhibitors. J Med Chem 2010 May 27;53(10):4066-84
1-((1-(4-fluorophenyl)-1H-pyrazol-4-yl)methyl)-4-phenylpiperazine  0   *Piperazines *Pyrazoles Ligands Receptor, Serotonin, 5-HT1A. Bioorg Med Chem 2010 Mar 1;18(5):1925-35
11-allyloxy-N-methylaporphine  0   *Aporphines Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2010 Feb 11;53(3):1319-28
11-propargyloxy-N-methylaporphine  0   *Aporphines Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2010 Feb 11;53(3):1319-28
N-methyl-2'-methyl-2',3'-dihydrofuro(m)aporphine  0   *Aporphines Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2010 Feb 11;53(3):1319-28
3-amino-5,6,7,8-tetrahydro-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)butyl)quinazolin-4-(3H)-one  0   *Quinolines *Quinazolinones Receptor, Serotonin, 5-HT1A/agonists Receptors, Serotonin, 5-HT3/agonists. J Pharmacol Exp Ther 2007 Sep;322(3):1315-23
2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5-(2H,4H)-dione  0   *Piperazines *Triazines Carbon Radioisotopes Receptor, Serotonin, 5-HT1A/agonists. Eur J Nucl Med Mol Imaging 2007 Jul;34(7):1050-60
3-chloro-4-fluorophenyl-(4-fluoro-4-(((5-methylpyrimidin-2-ylmethyl)amino)methyl)piperidin-1-yl)methanone  0   *Piperidines *Pyrimidines Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2007 Oct 4;50(20):5024-33
N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine  0   *Benzofurans *Benzylamines Receptors, Dopamine D2/antagonists & inhibitors Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2007 Feb 22;50(4):865-76
N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexane carboxamide  0   *Aminopyridines *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors Receptor, Serotonin, 5-HT1A/antagonists & inhibitors. Auton Autacoid Pharmacol 2005 Oct;25(4):185-9
6-methyl-2-(4-(naphthylpiperazin-1-yl)butyl)-3-(2H)-pyridazinone  0   *Piperazines *Pyridazines Receptor, Serotonin, 5-HT1A/agonists. Neuropharmacology 2006 Jul;51(1):129-40
3-(cyclobutyl(3-(5-fluoro-1H-indol-3-yl)propyl)amino)-8-fluorochromane-5-carboxamide  0   *Benzopyrans *Indoles Receptor, Serotonin, 5-HT1A/antagonists & inhibitors Serotonin Plasma Membrane Transport Proteins. J Med Chem 2006 Jul 27;49(15):4785-9
N-(3-(4-(4-cyclohexylmethanesulfonylaminobutyl)piperazin-1-yl)phenyl)acetamide  0   *Piperazines *Sulfonamides Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2006 Jun 1;49(11):3116-35
2-(4-(4-(7-methoxynaphthalen-1-yl)piperazin-1-yl)butyl)-4-methyl-2H-(1,2,4)triazine-3,5-dione  0   *Piperazines *Triazines Carbon Radioisotopes Ligands Receptor, Serotonin, 5-HT1A/agonists. J Med Chem 2006 Jan 12;49(1):125-34
cyclohexanecarboxylic acid, (2-methoxyphenyl)-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)amide  0   *Cyclohexanecarboxylic Acids *Piperazines Receptor, Serotonin, 5-HT1A/agonists. J Pharmacol Exp Ther 2005 Oct;315(1):109-17
cyclohexanecarboxylic acid (2-(4-(2-bromo-5-methoxybenzyl)piperazin-1-yl)ethyl)-(2-trifluoromethoxyphenyl)amide  0   *Cyclohexanecarboxylic Acids *Piperazines Receptor, Serotonin, 5-HT1A/agonists. J Pharmacol Exp Ther 2005 Oct;315(1):109-17
1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-((5-(4-fluorophenyl)-3-pyridinyl)methyl)piperazine  0   *Piperazines Receptor, Serotonin, 5-HT1A/agonists. Neuropharmacology 2005 Aug;49(2):135-43
lecozotan  0   *Dioxanes *Piperazines Receptor, Serotonin, 5-HT1A/antagonists & inhibitors. J Med Chem 2005 May 19;48(10):3467-70
8-((3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-hydroxypropyl)oxy)thiochroman  0   *Piperazines *Thiophenes Carbon Radioisotopes Receptor, Serotonin, 5-HT1A/agonists. Nucl Med Biol 2003 Jul;30(5):541-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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