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Receptors, Serotonin, 5-HT3

More information in Books or onNLM PubMed
Definition: A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; POTASSIUM; and CALCIUM.      Other names Receptors, Serotonin 3; Receptor, 5-Hydroxytryptamine-3; 5 Hydroxytryptamine 3 Receptor; 5 HT3 Receptor; Serotonin 3 Receptors; Receptor, Serotonin, 5-HT3E; Receptor, Serotonin, 5-HT3D; Receptor, Serotonin, 5-HT3C; Receptor, Serotonin, 5-HT3B; Receptor, Serotonin, 5-HT3A; Receptor, Serotonin, 5-HT3 Subunit E; Receptor, Serotonin, 5-HT3 Subunit D; Receptor, Serotonin, 5-HT3 Subunit C; Receptor, Serotonin, 5-HT3 Subunit B; Receptor, Serotonin, 5-HT3 Subunit A; Receptor, Serotonin 3; 5-Hydroxytryptamine-3 Receptor; 5-HT3 Receptor; Serotonin 3 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(3-ethoxyquinoxalin-2-yl)(4-methylpiperazin-1-yl)methanone  0   *Piperazines *Quinoxalines Receptors, Serotonin, 5-HT3. Bioorg Med Chem Lett 2011 Feb 15;21(4):1253-6
Lu AA21004  0   *Piperazines *Sulfides Receptor, Serotonin, 5-HT1A Receptors, Serotonin, 5-HT3. IDrugs 2010 Dec;13(12):900-10
(4-benzylpiperazin-1-yl)(quinoxalin-2-yl)methanone  0   *Piperazines *Quinoxalines Receptors, Serotonin, 5-HT3. Pharmacol Rep 2010 Mar-Apr;62(2):245-57
HTR3C protein, human  0   *Receptors, Serotonin, 5-HT3. Am J Med Genet B Neuropsychiatr Genet 2009 Jul 5;150B(5):741-6
3-(4-methoxybenzyl)-N-(3-(2-piperidin-1-yl)ethyl)-2,4-dioxoquinazoline-7-carboxamide  0   *Piperidines *Quinazolines Receptors, Serotonin, 5-HT3/antagonists & inhibitors. Bioorg Med Chem 2009 Jul 1;17(13):4793-6
3-amino-5,6,7,8-tetrahydro-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)butyl)quinazolin-4-(3H)-one  0   *Quinolines *Quinazolinones Receptor, Serotonin, 5-HT1A/agonists Receptors, Serotonin, 5-HT3/agonists. J Pharmacol Exp Ther 2007 Sep;322(3):1315-23
1-oxo-5-hydroxytryptamine  0   *Benzofurans Serotonin/*analogs & derivatives Receptors, Serotonin, 5-HT3/agonists. Org Lett 2007 Aug 16;9(17):3205-7
Htr3a protein, mouse  0   *Receptors, Serotonin, 5-HT3. J Pharmacol Exp Ther. 2006 Jun;317(3):1276-84
HTR3B protein, human  0   *Receptors, Serotonin, 5-HT3. Nature 1999 Jan 28;397(6717):359-63
HTR3A protein, human  0   *Receptors, Serotonin, 5-HT3. Psychiatr Genet 2005 Dec;15(4):303-4
5-chloro-7-methyl-2-(1-homopiperazinyl)benzoxazole  0   *Benzoxazoles *Piperazines Receptors, Serotonin, 5-HT3/agonists. J Med Chem 2005 Nov 3;48(22):7075-9
2-(4-allylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile  0   *Naphthyridines *Piperazines Receptors, Serotonin, 5-HT3/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Oct 18;14(20):5179-81
HTR3E protein, human  0   *Receptors, Serotonin, 5-HT3. Gene 2003 May 22;310:101-11
HTR3D protein, human  0   *Receptors, Serotonin, 5-HT3. Gene 2003 May 22;310:101-11
GR 65630  117186-80-8   *Imidazoles *Indoles Serotonin Antagonists Receptors, Serotonin, 5-HT3. Neurosci Lett 1988;94(1-2):156

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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