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Receptors, Serotonin, 5-HT4

More information in Books or onNLM PubMed
Definition: A subtype of G-protein-coupled SEROTONIN receptors that preferentially couple to GS STIMULATORY G-PROTEINS resulting in increased intracellular CYCLIC AMP. Several isoforms of the receptor exist due to ALTERNATIVE SPLICING of its mRNA.      Other names Receptors, Serotonin 4; Receptor, 5-Hydroxytryptamine-4; Receptor, 5-HT4S; Receptor, 5-HT4L; Receptor, 5-HT4; 5 Hydroxytryptamine 4 Receptor; 5 HT4S Receptor; 5 HT4L Receptor; 5 HT4 Receptor; Serotonin 4 Receptors; Receptor, Serotonin 4; 5-Hydroxytryptamine-4 Receptor; 5-HT4S Receptor; 5-HT4L Receptor; 5-HT4 Receptor; Serotonin 4 Receptor; Receptors, Serotonin, 5-HT4S; Receptors, Serotonin, 5-HT4L
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate  0   4-Aminobenzoic Acid/*analogs & derivatives Carbon Radioisotopes Ligands Receptors, Serotonin, 5-HT4. J Med Chem 2010 Oct 14;53(19):7035-47
CJ 033466  0   *Aminopyridines *Imidazoles Receptors, Serotonin, 5-HT4/agonists. J Pharmacol Sci 2007 Oct;105(2):207-10
6,7-dihydro-4-hydroxy-7-isopropyl-6-oxo-N-(3-(piperidin-1-yl)propyl)thieno(2,3-b)pyridine-5-carboxamide  0   *Pyridones *Thiophenes Receptors, Serotonin, 5-HT4/agonists. Neuropharmacology 2007 Sep;53(4):563-73
ATI 7505  0   *Benzamides *Quinuclidines Receptors, Serotonin, 5-HT4/agonists. Neurogastroenterol Motil 2007 Jan;19(1):30-8
hexahydro-1H-pyrrolizin-1-ylmethyl 1-methyl-1H-indole-3-carboxylate  0   *Indoles *Pyrrolizidine Alkaloids Receptors, Serotonin, 5-HT4/antagonists & inhibitors. J Med Chem 2006 Feb 9;49(3):1125-39
piboserod  152811-62-6   *Indoles *Oxazines Receptors, Serotonin, 5-HT4/antagonists & inhibitors. Eur J Pharmacol 2003 Apr 25;467(1-3):211-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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