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Receptors, Proteinase-Activated

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Definition: A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain cryptic ligands that are exposed upon the selective proteolysis of specific N-terminal cleavage sites.     
Examples Receptor, PAR-2; Receptors, Thrombin 		Other names Receptors, Proteinase Activated; Receptors, Protease-Activated; Receptors, Endopeptidase-Activated; Proteinase Activated Receptors; Protease Activated Receptors; Endopeptidase Activated Receptors; Proteinase-Activated Receptors; Protease-Activated Receptors; Endopeptidase-Activated Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
protease-activated receptor 4, mouse  0   *Receptors, Proteinase-Activated. Arterioscler Thromb Vasc Biol 2003 Jun 1;23(6);931-9
protease-activated receptor 3, mouse  0   *Receptors, Proteinase-Activated. Arterioscler Thromb Vasc Biol 2003 Jun 1;23(6);931-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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