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F-Box Proteins

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Definition: A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.     
See Also F-Box Motifs
Examples beta-Transducin Repeat-Containing Proteins 		Other names Protein, F-Box Domain; Protein Family, F-Box; F Box Proteins; F Box Protein Family; F Box Domain Protein; Domain Protein, F-Box; F-Box Protein Family; F-Box Domain Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Fbxo31 protein, mouse  0   *F-Box Proteins. Mol Cell Biol. 2012 Feb;32(3):590-605.
FBXL5 protein, mouse  0   *F-Box Proteins. Cell Metab. 2011 Sep 7;14(3):339-51.
FBXO7 protein, mouse  0   *F-Box Proteins. J Cell Sci. 2011 Jul 1;124(Pt 13):2175-86
AUF1 protein, Arabidopsis  0   *Arabidopsis Proteins *F-Box Proteins. Plant Physiol 2011 Aug;156(4):1878-93
Roy1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *F-Box Proteins. Mol Biol Cell 2011 May;22(9):1575-84
F-box and leucine-rich repeat protein 4, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases *F-Box Proteins. J Biol Chem 2011 Sep 2;286(35):30462-70
FBXO22 protein, human  0   *Receptors, Cytoplasmic and Nuclear *F-Box Proteins. Mol Cell Biol 2011 Sep;31(18):3687-99
Ppa protein, Xenopus  0   *Xenopus Proteins *F-Box Proteins. J Cell Biol. 2011 Jul 11;194(1):17-25
FBXL15 protein, zebrafish  0   *F-Box Proteins. EMBO J 2011;30(13):2675-89
FBXL15 protein, rat  0   *F-Box Proteins. EMBO J 2011;30(13):2675-89
FBXO39 protein, human  0   *F-Box Proteins. Biochem Biophys Res Commun 2011 May 6;408(2):195-201
AFB4 protein, Arabidopsis  0   *Receptors, Cell Surface *Arabidopsis Proteins F-Box Proteins. Curr Biol 2011 Mar 22;21(6):520-5
FBXL2 protein, mouse  0   *F-Box Proteins. Mol Cell Biol. 2011 May;31(9):1905-20
fsd protein, Drosophila  0   *Drosophila Proteins *F-Box Proteins. Nat Cell Biol. 2011 Jan;13(1):22-9
FBX8 protein, human  0   *F-Box Proteins. Mol Cells. 2010 Oct;30(4):355-62
nutcracker protein, Drosophila  0   *Drosophila Proteins *F-Box Proteins. Development 2010 May;137(10):1679-88
Fbxw7 protein, Xenopus  0   *Xenopus Proteins *F-Box Proteins. Neural Dev. 2010;5() (dup#4):1
FBXL14 protein, human  EC 6.3.2.19   *F-Box Proteins *Ubiquitin-Protein Ligases. J Biol Chem 2010 Feb 5;285(6):3794-805
CPR30 protein, Arabidopsis  0   *Arabidopsis Proteins *F-Box Proteins. Plant J 2009 Dec;60(5):757-70
Emi2 protein, rat  0   *F-Box Proteins. PLoS One 2009;4(10):e7237
atrogin-1 protein, zebrafish  0   *Zebrafish Proteins *F-Box Proteins. FASEB J 2009 Sep;23(9):2844-54
Fbxo45 protein, mouse  0   *F-Box Proteins. Mol Cell Biol 2009 Jul;29(13):3529-43
JFK protein, human  0   *F-Box Proteins. Proc Natl Acad Sci U S A 2009 Jun 23;106(25):10195-200
FBXW5 protein, human  0   *F-Box Proteins. Biochem Biophys Res Commun 2009 Apr 10;381(3):412-7
DOR protein, Arabidopsis  0   *Arabidopsis Proteins *F-Box Proteins. Plant Physiol 2008 Dec;148(4):2121-33
KDM2A protein, human  EC 1.5.-   *Oxidoreductases, N-Demethylating *F-Box Proteins. Cell Cycle. 2008 Nov 15;7(22):3539-47
Fbx3 protein, human  0   *F-Box Proteins. Mol Cell Biol 2008 Dec;28(23):7126-38
FBXO43 protein, human  0   *F-Box Proteins. Mol Biol Cell 2008 Aug;19(8):3536-43
DFsn protein, Drosophila  0   *Drosophila Proteins *F-Box Proteins. Neural Develop 2007;2:16
FBXL21 protein, human  0   *F-Box Proteins. Am J Med Genet B Neuropsychiatr Genet 2008 Oct 5;147B(7):1231-7
Fbx8 protein, mouse  0   *F-Box Proteins. Mol Biol Cell 2008 Mar;19(3):822-32
F-box family protein 17, Arabidopsis thaliana  0   *Arabidopsis Proteins *F-Box Proteins. Nature 2008 Oct 23;455(7216):1134-7
FBXL17 protein, human  0   *F-Box Proteins Tumor Markers, Biological. Cancer Genomics Proteomics. 2008 May-Aug;5(3-4):151-60
FSN-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *F-Box Proteins Ubiquitin-Protein Ligases. Nature 2004 Jul 15;430(6997):345-50
Fbl6 protein, human  0   *F-Box Proteins. Mol Cell Biol 2008 Jul;28(13):4394-406
Arp8 protein, Arabidopsis  0   *Arabidopsis Proteins *F-Box Proteins. Plant Cell Physiol 2008 May;49(5):858-63
Fbxw15 protein, mouse  0   *F-Box Proteins. Biol Reprod 2008 Apr;78(4):714-25
XAF1 protein, mouse  0   *F-Box Proteins Zinc Fingers. J Biol Chem 2008 Mar 14;283(11):6832-42
SKP2A protein, Arabidopsis  0   *Arabidopsis Proteins *F-Box Proteins. Plant J 2008 Mar;53(5):828-41
FBW5 protein, human  0   *F-Box Proteins. Genes Dev 2008 Apr 1;22(7):866-71
PROM-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *F-Box Proteins. Mol Biol Cell 2007 Dec;18(12):4911-20
FBXW8 protein, human  0   *F-Box Proteins. Mol Cell Biol 2008 Jan;28(2):743-51
FBXO40 protein, rat  0   *F-Box Proteins. Gene 2007 Dec 1;404(1-2):53-60
FBXO40 protein, mouse  0   *F-Box Proteins. Gene 2007 Dec 1;404(1-2):53-60
FBXO40 protein, human  0   *F-Box Proteins. Gene 2007 Dec 1;404(1-2):53-60
Kdm2b protein, mouse  EC 1.14.11.27   *F-Box Proteins *Jumonji Domain-Containing Histone Demethylases. Mol Cell Proteomics 2007 May;6(5):820-34
Scirr1 protein, rat  0   *F-Box Proteins. Exp Mol Med 2007 Jun 30;39(3):255-66
FBXL5 protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases *F-Box Proteins. Biochem Biophys Res Commun 2007 Jul 10;359(1):34-9
FBXL3 protein, human  0   *F-Box Proteins. Science 2007 May 11;316(5826):900-4
Fbxl3 protein, mouse  0   *F-Box Proteins. Science 2007 May 11;316(5826):897-900
DRE-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *F-Box Proteins. Dev Cell 2007 Mar;12(3):443-55
Fbx15 protein, mouse  0   *F-Box Proteins. Mol Cell Biol 2003 Apr;23(8):2699-708
Fbxo11 protein, mouse  0   *F-Box Proteins. Hum Mol Genet 2006 Nov 15;15(22):3273-9
Fbx4 protein, mouse  0   *F-Box Proteins. Mol Cell 2006 Nov 3;24(3):355-66
Pof3 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *F-Box Proteins Protein Subunits. Mol Biol Cell 2002 Jan;13(1):211-24
Pof14 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *F-Box Proteins. EMBO J 2006 Oct 4;25(19):4547-56
Mfb1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *F-Box Proteins Mitochondrial Proteins. Mol Biol Cell 2006 Sep;17(9):3745-55
TLP9 protein, Arabidopsis  0   *Arabidopsis Proteins *F-Box Proteins. Plant Physiol 2004 Apr;134(4):1586-97
Fbxw8 protein, mouse  0   *F-Box Proteins. Mol Cell Biol 2006 Aug;26(16):6157-69
FBXW7 protein, human  EC 6.3.2.19   *Cell Cycle Proteins *Ubiquitin-Protein Ligases *F-Box Proteins.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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