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DNA Repair Enzymes

More information in Books or onNLM PubMed
Definition: Enzymes that are involved in the reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule, which contained damaged regions.  GEN; prefer specifics; coord with specific enzyme not treed here   
See Also DNA Damage; DNA Repair
Examples Deoxyribodipyrimidine Photo-Lyase; DNA Glycosylases; DNA Ligases; DNA-(Apurinic or Apyrimidinic Site) Lyase; MutS DNA Mismatch-Binding Protein; MutS Homolog 2 Protein; Polynucleotide 5'-Hydroxyl-Kinase 		Other names Repair Enzymes, DNA; Enzymes, DNA Repair
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ERCC1 protein, rat  EC 6.5.1.-   *DNA Repair Enzymes. Biochem Biophys Res Commun 2011 May 20;408(4):595-601
NDX-4 protein, C elegans  EC 3.1.6.-   *Phosphoric Monoester Hydrolases *Caenorhabditis elegans Proteins DNA Repair Enzymes. DNA Repair (Amst) 2011 Feb 7;10(2):176-87
Tdp1 protein, S pombe  0   *Phosphoric Diester Hydrolases *Schizosaccharomyces pombe Proteins DNA Repair Enzymes. EMBO J 2009 Mar;18;28(6):632-40
PNKP protein, human  EC 2.7.1.-   *Phosphotransferases (Alcohol Group Acceptor) *DNA Repair Enzymes. Eur J Cancer Prev 2008 Jun;17(3):287-90
MGMT protein, mouse  EC 2.1.1.63   *DNA Modification Methylases *Tumor Suppressor Proteins *DNA Repair Enzymes. Carcinogenesis 2008 Apr;29(4):866-74
ATRIP protein, human  0   *DNA-Binding Proteins *Adaptor Proteins, Signal Transducing DNA Repair Enzymes.
MGMT protein, human  EC 2.1.1.63   *DNA Modification Methylases *Tumor Suppressor Proteins *DNA Repair Enzymes. J Pathol. 2006 Nov;210(3):344-50
TEL1 protein, S cerevisiae  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Saccharomyces cerevisiae Proteins *Intracellular Signaling Peptides and Proteins DNA Repair Enzymes.
RAD23B protein, human  0   *DNA-Binding Proteins *DNA Repair Enzymes.
Ercc6 protein, mouse  0   *DNA Repair Enzymes.
Ercc6 protein, rat  EC 3.6.1.-   *DNA Helicases *DNA Repair Enzymes.
Mre11a protein, rat  0   *DNA-Binding Proteins *DNA Repair Enzymes. RGD ID 69263
Mre11a protein, mouse  0   *DNA-Binding Proteins *DNA Repair Enzymes.
ABH3 protein, mouse  EC 1.14.11.-   *DNA Repair Enzymes *Dioxygenases. EMBO J 2006 May 17;25(10):2189-98
Alkbh2 protein, mouse  EC 1.14.11.-   *DNA Repair Enzymes *Dioxygenases. EMBO J 2006 May 17;25(10):2189-98
NHEJ1 protein, human  0   *DNA-Binding Proteins *DNA Repair Enzymes DNA Repair. Cell 2006 Jan 27;124(2):287-9
MLH1 protein, human  0   *Nuclear Proteins *Adaptor Proteins, Signal Transducing DNA Repair DNA Repair Enzymes.
MutLalpha protein, human  0   *DNA Repair Enzymes DNA Repair Base Pair Mismatch. Mol Carcinog 2005 May;43(1):51-8
Pms2 protein, mouse  EC 3.6.1.-   *Adenosine Triphosphatases *DNA-Binding Proteins *DNA Repair Enzymes DNA Repair Neoplasm Proteins Base Pair Mismatch.
ALKBH1 protein, human  0   *DNA Repair Enzymes.
DCLRE1B protein, human  0   *Nuclear Proteins *DNA Repair Enzymes. Oncogene. 2004 Nov 11;23(53):8611-8
Rad50 protein, Drosophila  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Drosophila Proteins DNA Repair Enzymes. Curr Biol 2004 Aug 10;14(15):1360-6
Mre11 protein, Drosophila  EC 3.1.-   *Endodeoxyribonucleases *Drosophila Proteins DNA Repair Enzymes. Curr Biol 2004 Aug 10;14(15):1348-53
ALKBH2 protein, human  0   *DNA Repair Enzymes *Dioxygenases DNA Repair. Nucleic Acids Res 2004;32(4):1548-54
ALKBH3 protein, human  EC 1.14.11.-   *Dioxygenases *DNA Repair Enzymes DNA Repair. Nucleic Acids Res 2004;32(4):1548-54
PRPF19 protein, human  EC 6.5.1.-   *Nuclear Proteins *DNA Repair Enzymes. Exp Cell Res 2000 Nov 25;261(1):166-79
EXO1 protein, human  EC 3.1.-   *Exodeoxyribonucleases *DNA Repair Enzymes. Nucleic Acids Res 1998 Aug 15;26(16):3762-8
Rad50 protein, human  0   *DNA-Binding Proteins *DNA Repair Enzymes. Cell 1998 May 1;93(3):477-86
Mus308 protein, Drosophila  0   *Drosophila Proteins *DNA Repair Enzymes DNA Polymerase I DNA Helicases. Mol Cell Biol 1996 Oct;16(10):5764-71
ERCC8 protein, human  0   *Transcription Factors *DNA Repair Enzymes Cockayne Syndrome. Cell 1995 Aug 25;82(4):555-64
PMS2 protein, human  EC 3.6.1.-   *Adenosine Triphosphatases *DNA-Binding Proteins *DNA Repair Enzymes DNA Repair Neoplasm Proteins Base Pair Mismatch. Cell 1995 Jul 28;82(2):309-19; Nature 1994 Sep 1;371(6492):75-80
RAD23A protein, human  156533-33-4   *DNA-Binding Proteins *DNA Repair Enzymes DNA Repair. EMBO J 1994 Apr 15;13(8):1831-43
Apn1 protein, S cerevisiae  EC 3.1.25.-   *Endodeoxyribonucleases *Saccharomyces cerevisiae Proteins *DNA Repair Enzymes DNA Repair. J Biol Chem 1993 Sep 25;268(27):20533-9
ERCC6 protein, human  EC 3.6.1.-   *DNA Helicases *DNA Repair Enzymes Cockayne Syndrome DNA Repair. Cell 1992 Dec 11;71(6):939-53
8-oxodGTPase  EC 3.1.6.-   *Phosphoric Monoester Hydrolases *DNA Repair Enzymes Antimutagenic Agents. Proc Natl Acad Sci U S A 1992 Nov 15;89(22):11021-5
RAD54 protein, S cerevisiae  EC 3.6.1.-   *DNA Helicases *Saccharomyces cerevisiae Proteins *DNA Repair Enzymes. Yeast 1992 May;8(5):385-95
RAD14 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *DNA Repair Enzymes. Nature 1992 Feb 6;355(6360):555-8
RAD57 protein, S cerevisiae  EC 3.6.1.-   *Adenosine Triphosphatases *Saccharomyces cerevisiae Proteins *DNA Repair Enzymes. Gene 1991;105(1):139
RAD1 protein, S cerevisiae  EC 3.1.-   *Endonucleases *Saccharomyces cerevisiae Proteins *DNA Repair Enzymes DNA Repair. FEBS Lett 1991;283(2):203
methyl-directed mismatch repair protein, E coli  EC 3.1.21.-   *DNA-Binding Proteins *Endodeoxyribonucleases *Escherichia coli Proteins *DNA Repair Enzymes DNA Repair. Gene 1988;74(1):211
UvsD protein, Deinococcus radiodurans  EC 3.1.25.-   *Bacterial Proteins *Endodeoxyribonucleases *DNA Repair Enzymes. Biosci Biotechnol Biochem. 2003 Mar;67(3):613-6; Int J Mol Med. 2003 Nov;12(5):741-7; Mutat Res 1988;207(3-4):117

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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