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beta-Lactams

More information in Books or onNLM PubMed
Definition: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.     
Pharmacological Action Anti-Bacterial Agents
Examples Carbapenems; Cephalosporins; Clavulanic Acids; Monobactams; Moxalactam; Penicillins 		Other names beta Lactams; 4-Thia-1-Azabicyclo(4.2.0)Octanes; 4-Thia-1-Azabicyclo(3.2.0)Heptanes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
monamphilectine A  0   *Diterpenes *beta-Lactams. Org Lett. 2010 Nov 19;12(22):5290-3
faropenem medoxomil  0   *beta-Lactams. Otolaryngol Head Neck Surg 2006 Oct;135(4):511-7
ertapenem  0 (4R,5R,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid  *beta-Lactams.
Pharma Action Anti-Bacterial Agents 		Expert Opin Investig Drugs 2001 Jun;10(6):1157-66INVANZ
fropenem  106560-14-9   *beta-Lactams. J Antimicrob Chemother 1997 Mar;39(3):415-8
T 5575  0   *beta-Lactams. Antimicrob Agents Chemother 1995 Sep;39(9):2132-4; J Antimicrob Chemother. 1997 Jan;39(1):31-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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