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Protein Kinase Inhibitors

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Definition: Agents that inhibit PROTEIN KINASES.      Other names Kinase Inhibitors, Protein; Inhibitors, Protein Kinase
Substances having this pharmacologic action: N(6),N(6)-dimethyladenine; Phosphatidylethanolamine Binding Protein; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase Inhibitor p57; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p19; wortmannin; Genistein; Emodin; adenosine-3',5'-cyclic phosphorothioate; SU 5416; erlotinib; vatalanib; gefitinib; sorafenib; dasatinib; lapatinib; crizotinib; imatinib; roscovitine; flavopiridol; 1-(5-isoquinolinylsulfonyl)-3-methylpiperazine; butyrolactone I; KN 93; KT 5823; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide; 7-hydroxystaurosporine; fasudil; N-(2-guanidinoethyl)-5-isoquinolinesulfonamide; N-(2-aminoethyl)-5-isoquinolinesulfonamide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(2,6-diethylphenyl)-1-methyl-8-((4-((1-methylpiperidin-4-yl)carbamoyl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide  0   *Pyrazoles *Quinazolines Protein Kinase Inhibitors. Cancer Res 2010 Dec 15;70(24):10255-64
HH-GV-678  0   *Aminopyridines *Benzamides Protein Kinase Inhibitors. Leukemia. 2010 Oct;24(10):1807-9
bafetinib  859212-16-1   *Pyrimidines Protein Kinase Inhibitors. Blood 2005 Dec 1;106(12):3948-54
CP-654577  0   *Quinazolines Protein Kinase Inhibitors. Cancer Res. 2003 Aug 1;63(15):4450-9
BIRB 796  0   *Naphthalenes *Pyrazoles Protein Kinase Inhibitors. Nat Struct Biol 2002 Apr;9(4):268-72
temsirolimus  0   Sirolimus/*analogs & derivatives Antineoplastic Agents Protein Kinase Inhibitors. Bull Cancer 1999 Oct;86(10):808-11TORISEL
HA 1100  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Protein Kinase Inhibitors. Eur J Pharmacol 1998 Nov 6;360(2-3):257-64
3-isomangostin  0   *Xanthones Protein Kinase Inhibitors. Chem Biol Interact 1998 Jul 3;114(1-2):121-40
9-phenanthrol  484-17-3   *Phenanthrenes Protein Kinase Inhibitors. Biol Chem Hoppe Seyler 1994 Aug;375(8):527-35
4-methyl-5-(4-pyridinyl)-2(3H)-oxazolone  132338-12-6   Oxazolone/*analogs & derivatives Protein Kinase Inhibitors. J Cell Physiol 1992 Sep;152(3):448-57
KN 04  129695-80-3   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Protein Kinase Inhibitors. J Pharmacol Exp Ther 1990;254(2):598
NA 0344  120925-59-9 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 10-((dimethylamino)methyl)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-, (9S-(9alpha,10beta,12alpha))  *Carbazoles Protein Kinase Inhibitors. Life Sci 1989;44(19):1351
IP 20  99534-03-9   *Peptides Protein Kinase Inhibitors. Biochem J 1989 Feb 1;257(3):715-21; Cell Regul 1990 Dec;1(13):1015-25
2-isobutyl-3-oxo-4-chloro-2-butylcarbonate  81652-49-5 Carbonic acid, 3-chloro-1-methyl-2-oxopropyl 2-methylpropyl ester  *Lactates Hexokinase/antagonists & inhibitors Protein Kinase Inhibitors/antagonists & inhibitors. Biochemistry 1982;21(12):2984
indirubin  479-41-4   Indoles Leukemia, Myelogenous, Chronic, BCR-ABL Positive Protein Kinase Inhibitors.
Pharma Action Antibiotics, Antineoplastic ; Coloring Agents 		Chung Kuo I Hsueh Ko Huseh Yuan Hsueh Pao 1980;2(2):83
mangostin  6147-11-1 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2- butenyl)-9H-xanthen-9-one  *Xanthones Protein Kinase Inhibitors. Arch Int Pharmacodyn Ther 239(2):257;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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