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PPAR alpha

More information in Books or onNLM PubMed
Definition: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.      Other names PPARalpha; Peroxisome Proliferator Activated Receptor alpha; Peroxisome Proliferator-Activated Receptor alpha
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(S)-2-(2,4-hexadienoyl)-7-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid  0   *Tetrahydroisoquinolines PPAR alpha/agonists PPAR gamma/agonists. Chem Pharm Bull (Tokyo). 2011;59(7):876-9
2-(((4-methoxyphenoxy)carbonyl)(1-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)ethyl)amino)acetic acid  0   *Oxazoles Glycine/*analogs & derivatives PPAR alpha/agonists PPAR gamma/agonists. Drug Metab Dispos 2011 Feb;39(2):228-38
CG 301269  0   *Oxazoles *Thiazolidines PPAR alpha/agonists PPAR gamma/agonists. Diabetes 2011 Feb;60(2):496-506
1-(4-(2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy)benzyl)piperidine-2-carboxylic acid  0   *Oxazoles *Pipecolic Acids PPAR alpha/agonists PPAR gamma/agonists. Mol Pharmacol 2010 Nov;78(5):877-85
3-(3-(1-carboxy-1-methylethoxy)phenyl)piperidine-1-carboxylic acid 4-trifluoromethylbenzyl ester  0   *Piperidines *Propionic Acids PPAR alpha/agonists. J Pharmacol Exp Ther 2010 Jun;333(3):844-53
2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid  0   *Oxazoles Glycine/*analogs & derivatives PPAR alpha/agonists. J Med Chem 2010 Apr 8;53(7):2854-64
lobeglitazone  0   *Pyrimidines *Thiazolidinediones PPAR alpha/agonists PPAR gamma/agonists. J Pharm Biomed Anal 2009 Dec 5;50(5):872-7
2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid  0   *Oxazoles *Benzoic Acids PPAR alpha/agonists. Acta Pharmacol Sin 2009 Jul;30(7):935-46
2-(4-(2-Fluoro-benzenesulphonyl)-piperazin-1-yl)-3-(4-(2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy)phenyl)propionic acid  0   *Phenylpropionates *Sulfonamides PPAR alpha/agonists PPAR gamma/agonists. Br J Pharmacol 2009 Jul;157(5):724-35
2-methyl-2-((1-(3-phenyl-7-propylbenzo(d)isoxazol-6-yl)oxy)propyl)-1H-4-indolyloxypropanoic acid  0   *Indoles *Propionic Acids DNA Topoisomerases, Type II/antagonists & inhibitors PPAR alpha/agonists PPAR gamma/agonists. Anticancer Drugs 2008 Feb;19(2):151-8
methyl 7-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)coumarin-7-carboxylate  0   *Coumarins *Oxazoles PPAR alpha/agonists PPAR gamma/agonists. Bioorg Med Chem Lett 2003 Oct 20;13(20):3437-40
2-methyl-2-(4-(((4-methyl-2-(4-trifluoromethylphenyl)-thiazol-5-ylcarbonyl)amino)methyl)phenoxy)propionic acid  0   *Propionic Acids *Thiazoles PPAR alpha/agonists. J Med Chem 2007 Feb 22;50(4):685-95
naveglitazar  0   *Phenylpropionates PPAR alpha/agonists PPAR gamma/agonists. Drug Metab Dispos 2007 Jan;35(1):51-61
N-octadecyl-N'-propylsulfamide  0   *Sulfonamides PPAR alpha/agonists. J Med Chem 2007 Jan 25;50(2):389-93
3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(2-(2-nitrophenoxy)acetylamino)propionic acid  0   *Oxazoles Tyrosine/*analogs & derivatives PPAR alpha/agonists PPAR gamma/agonists. Biotechnol Lett 2006 Jun;28(12):863-8
2-ethyl-5-(3-(2-chloro-4-(trifluoromethoxy)phenoxy)propoxy)-2,3-dihydro-1-benzofuran-2-carboxylic acid  0   *Benzofurans PPAR alpha/agonists. J Med Chem 2005 Aug 25;48(17):5589-99
2-(4-chlorophenoxy)-3-phenylpropanoic acid  0   *Phenylpropionates PPAR alpha/agonists PPAR gamma/agonists. J Med Chem 2005 Aug 25;48(17):5509-19
2-ethoxy-3-(4-((4-(methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid  0   *Alkanesulfonates *Phenylpropionates PPAR alpha/agonists PPAR gamma/agonists. Drug Metab Dispos 2004 Sep;32(9):923-9
2-((5,7-dipropyl-3-trifluoromethyl)benzisoxazol-6-yloxy)-2-methylpropionic acid  0   *Isoxazoles *Propionic Acids PPAR alpha/agonists PPAR gamma/agonists. J Med Chem 2005 Apr 7;48(7):2262-5
muraglitazar  0 2-((4-methoxyphenoxy)carbonyl-((4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)methyl)amino)acetic acid  *Oxazoles Glycine/*analogs & derivatives Phenoxybenzamine PPAR alpha/agonists PPAR gamma/agonists. J Med Chem 2005 Mar 24;48(6):2148-50
L 663536  118414-82-7 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)  *Indoles PPAR alpha/antagonists & inhibitors.
Pharma Action Lipoxygenase Inhibitors 		Can J Physiol Pharmacol 1989;67(5):456

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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