encyclopedia of medical concepts
ψ 
ψ 
ψ 

PPAR gamma

More information in Books or onNLM PubMed
Definition: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.      Other names PPARgamma; Receptor, Thiazolidinedione; Peroxisome Proliferator Activated Receptor gamma; mPPARgamma2; mPPARgamma1; Thiazolidinedione Receptor; Peroxisome Proliferator-Activated Receptor gamma; PPARgamma3; PPARgamma2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(2,4-hexadienoyl)-7-(2-(5-methyl-2-(5-methylhexen-1-yl)oxazol-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid  0   *Isoquinolines *Oxazoles PPAR gamma/agonists. Bioorg Med Chem. 2012 Jan 15;20(2):1060-75.
5-(3-((3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl)methyl)phenyl)-5-methyloxazolidinedione  0   *Benzimidazoles Dimethadione/*analogs & derivatives PPAR gamma. J Med Chem. 2011 Dec 22;54(24):8541-54.
(S)-2-(2,4-hexadienoyl)-7-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid  0   *Tetrahydroisoquinolines PPAR alpha/agonists PPAR gamma/agonists. Chem Pharm Bull (Tokyo). 2011;59(7):876-9
3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-isobutyl-7-methyl-3H-imidazo(4,5-b)pyridine  0   *Imidazoles *Pyridines Angiotensin II Type 1 Receptor Blockers PPAR gamma/agonists. J Med Chem 2011 Jun 23;54(12):4219-33
5-(5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid  0   *Aminobenzoic Acids *Thiazolidines PPAR gamma/antagonists & inhibitors. J Steroid Biochem Mol Biol 2011 Apr;124(3-5):112-20
2-(((4-methoxyphenoxy)carbonyl)(1-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)ethyl)amino)acetic acid  0   *Oxazoles Glycine/*analogs & derivatives PPAR alpha/agonists PPAR gamma/agonists. Drug Metab Dispos 2011 Feb;39(2):228-38
CG 301269  0   *Oxazoles *Thiazolidines PPAR alpha/agonists PPAR gamma/agonists. Diabetes 2011 Feb;60(2):496-506
2-ethoxy-3-(4-(3-methyl-5-(4-(3-methylisoxazol-5-yl)phenyl)thiophen-2-ylmethoxy)phenyl)propionic acid  0   *Phenylpropionates *Thiophenes PPAR gamma/agonists. Arch Pharm Res 2010 Sep;33(9):1389-94
(E)-12-nitrooctadec-12-enoic acid  0   *Linoleic Acids *Nitro Compounds PPAR gamma/agonists. J Org Chem. 2010 Dec 3;75(23):8311-4
(5-(3-(4-(biphenyl-4-ylcarbonyl)phenoxy)propoxy)-1H-indol-1-yl)acetic acid  0   *Benzophenones *Indoleacetic Acids PPAR gamma/agonists. ChemMedChem 2010 Oct 4;5(10):1707-16
1-(4-(2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy)benzyl)piperidine-2-carboxylic acid  0   *Oxazoles *Pipecolic Acids PPAR alpha/agonists PPAR gamma/agonists. Mol Pharmacol 2010 Nov;78(5):877-85
lobeglitazone  0   *Pyrimidines *Thiazolidinediones PPAR alpha/agonists PPAR gamma/agonists. J Pharm Biomed Anal 2009 Dec 5;50(5):872-7
2-(4-(2-Fluoro-benzenesulphonyl)-piperazin-1-yl)-3-(4-(2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy)phenyl)propionic acid  0   *Phenylpropionates *Sulfonamides PPAR alpha/agonists PPAR gamma/agonists. Br J Pharmacol 2009 Jul;157(5):724-35
1-0-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocoline  0   Phosphorylcholine/*analogs & derivatives PPAR gamma/agonists. Cerebellum. 2009 Jun;8(2):98-103
INT 131  0   *Quinolines *Sulfonamides PPAR gamma/agonists. Curr Opin Investig Drugs 2009 Apr;10(4):381-7
2-(1-(3-(4-(biphenyl-4-carbonyl)-2-propylphenoxy)propyl)-1,2,3,4-tetrahydroquinolin-5-yloxy)-2-methylpropionic acid  0   *Hydroxybutyrates *Quinolines PPAR gamma/agonists. J Med Chem 2009 Apr 23;52(8):2618-22
KR 62776  0   *Indans *Oximes PPAR gamma/agonists. Biochem Biophys Res Commun 2009 Jan 16;378(3):645-9
KV-5070  0   *Tetrahydroisoquinolines PPAR gamma/agonists. Naunyn Schmiedebergs Arch Pharmacol 2008 Jun;377(4-6):401-10
2-methyl-2-((1-(3-phenyl-7-propylbenzo(d)isoxazol-6-yl)oxy)propyl)-1H-4-indolyloxypropanoic acid  0   *Indoles *Propionic Acids DNA Topoisomerases, Type II/antagonists & inhibitors PPAR alpha/agonists PPAR gamma/agonists. Anticancer Drugs 2008 Feb;19(2):151-8
4-hydroxydocasahexaenoic acid  0   *Fatty Acids, Unsaturated PPAR gamma/agonists. Biochem Biophys Res Commun 2008 Mar 14;367(3):566-72
2-cyanolup-1-en-3-oxo-20-oic acid  0   *Triterpenes PPAR gamma/agonists. Carcinogenesis 2007 Nov;28(11):2337-46
methyl 7-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)coumarin-7-carboxylate  0   *Coumarins *Oxazoles PPAR alpha/agonists PPAR gamma/agonists. Bioorg Med Chem Lett 2003 Oct 20;13(20):3437-40
naveglitazar  0   *Phenylpropionates PPAR alpha/agonists PPAR gamma/agonists. Drug Metab Dispos 2007 Jan;35(1):51-61
2-bromo-5-nitro-N-phenylbenzamide  0   *Anilides *Benzamides Bromine Radioisotopes PPAR gamma/antagonists & inhibitors. Nucl Med Biol 2006 Oct;33(7):847-54
3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(2-(2-nitrophenoxy)acetylamino)propionic acid  0   *Oxazoles Tyrosine/*analogs & derivatives PPAR alpha/agonists PPAR gamma/agonists. Biotechnol Lett 2006 Jun;28(12):863-8
3-(4-(3-(4-chloro-2-phenoxyphenoxy)butoxy)-2-ethylphenyl)propionic acid  0   *Phenyl Ethers *Phenylpropionates PPAR delta/agonists PPAR gamma/agonists. J Med Chem 2006 Sep 21;49(19):5649-52
N-(2-(4-((2,4-dioxo-1,3-thiazolidin-5-yl)methyl)phenoxy)ethyl)-5-(1,2-dithiolan-3-yl)-N-methylpentanamide  0   *Thiazolidinediones Thioctic Acid/*analogs & derivatives PPAR gamma/agonists. J Med Chem 2006 Jul 13;49(14):4072-84
1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester  0   *Indenes *Morpholines PPAR gamma/agonists. Biochem Pharmacol 2006 Aug 14;72(4):446-54
1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester  0   *Indenes PPAR gamma/agonists. J Med Chem 2006 Jul 27;49(15):4781-4
1,1-bis(3'-indolyl)-1-(4-biphenyl)methane  0   *Indoles PPAR gamma/agonists. J Vasc Res 2005 Nov-Dec;42(6):509-16
1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane  0   *Indoles PPAR gamma/agonists. J Vasc Res 2005 Nov-Dec;42(6):509-16
2-(4-chlorophenoxy)-3-phenylpropanoic acid  0   *Phenylpropionates PPAR alpha/agonists PPAR gamma/agonists. J Med Chem 2005 Aug 25;48(17):5509-19
2-ethoxy-3-(4-((4-(methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid  0   *Alkanesulfonates *Phenylpropionates PPAR alpha/agonists PPAR gamma/agonists. Drug Metab Dispos 2004 Sep;32(9):923-9
2-((5,7-dipropyl-3-trifluoromethyl)benzisoxazol-6-yloxy)-2-methylpropionic acid  0   *Isoxazoles *Propionic Acids PPAR alpha/agonists PPAR gamma/agonists. J Med Chem 2005 Apr 7;48(7):2262-5
muraglitazar  0 2-((4-methoxyphenoxy)carbonyl-((4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)methyl)amino)acetic acid  *Oxazoles Glycine/*analogs & derivatives Phenoxybenzamine PPAR alpha/agonists PPAR gamma/agonists. J Med Chem 2005 Mar 24;48(6):2148-50
rosiglitazone  122320-73-4 2,4-Thiazolidinedione, 5-004-02-((((methyl-2-pyridinylamino)ethoxy)phenyl)methyl)  *Thiazolidinediones Fibrinolytic Agents Vasodilator Agents PPAR gamma.
Pharma Action Hypoglycemic Agents
Diabetes 1994 Oct;43(10):1203-10ROSIGLITAZONE; ROSIGLITAZONE MALEATE; GLIMEPIRIDE; AVANDIA; ROSIGLITAZONE MALEATE

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify.
We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy