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Receptors, Tumor Necrosis Factor, Type I

More information in Books or onNLM PubMed
Definition: A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.      Other names Receptor, TNFRSF1A; Antigen, CD120a; Antigen, CD 120a; 120a Antigen, CD; Tumor Necrosis Factor Receptor Type 1; Tumor Necrosis Factor Receptor 1A; TNFRSF1A Receptor; TNFRSF1A (Tumor Necrosis Factor Receptor Superfami; TNFR1; CD120a Antigen; CD 120a Antigen; TNFR-I; TNFR p60; Tumor Necrosis Factor Receptor Type I; Tumor Necrosis Factor Receptor Superfamily, Member; Receptors, Tumor Necrosis Factor, Member 1A; CD120a Antigens; Antigens, CD120a
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Tnfrsf1a protein, rat  0   *Receptors, Tumor Necrosis Factor, Type I.
Tnfrsf1a protein, mouse  0   *Receptors, Tumor Necrosis Factor, Type I.
TNFRSF1A protein, human  0   *Receptors, Tumor Necrosis Factor, Type I.
PEGylated tumor necrosis factor alpha receptor 1  0   *Polyethylene Glycols *Receptors, Tumor Necrosis Factor, Type I Tumor Necrosis Factor-alpha/antagonists & inhibitors. Arthritis Rheum 2005 Jan;52(1):128-35
recombinant human tumor necrosis factor-binding protein-1  0   *Receptors, Tumor Necrosis Factor, Type I *Tumor Necrosis Factor Decoy Receptors Polyethylene Glycols Recombinant Proteins. Biotherapy 1991;3(2):159; Exp Neurol 1995 Feb;131(2):221-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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