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Intracellular Signaling Peptides and Proteins

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Definition: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.  don't confuse with SIGNAL PEPTIDES entry term to PROTEIN SORTING SIGNALS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS is also available   
Examples 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Activating Transcription Factor 6; Adaptor Proteins, Signal Transducing; Adenylate Cyclase; AMP-Activated Protein Kinases; Apoptosis Regulatory Proteins; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinases; Cold Shock Proteins and Peptides; Cyclic Nucleotide-Regulated Protein Kinases; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Cyclins; Dual-Specificity Phosphatases; eIF-2 Kinase; Focal Adhesion Protein-Tyrosine Kinases; G-Protein-Coupled Receptor Kinases; Glycogen Synthase Kinases; GTP-Binding Protein Regulators; Guanylate Cyclase; Heterotrimeric GTP-Binding Proteins; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1 Receptor-Associated Kinases; Intracellular Calcium-Sensing Proteins; Lim Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinase Phosphatases; Mitogen-Activated Protein Kinases; Monomeric GTP-Binding Proteins; Mucin-4; Olfactory Marker Protein; p21-Activated Kinases; Phosphatidylethanolamine Binding Protein; Phosphoinositide Phospholipase C; Phospholipase C gamma; Protein Phosphatase 2; Protein Tyrosine Phosphatases, Non-Receptor; Receptor-Like Protein Tyrosine Phosphatases; rho-Associated Kinases; Ribosomal Protein S6 Kinases; SH2 Domain-Containing Protein Tyrosine Phosphatases 		Other names Signaling Proteins, Intracellular; Signaling Peptides, Intracellular; Proteins, Intracellular Signaling; Peptides, Intracellular Signaling; Intracellular Signaling Proteins; Intracellular Signaling Peptides
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
brain-derived integrating factor-1, rat  0   *Intracellular Signaling Peptides and Proteins. Neurosci Res. 2011 Jul;70(3):330-3
deptor protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Mol Med. 2011 Sep-Oct;17(9-10):925-36.
Plekha5 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Gene. 2012 Jan 15;492(1):270-5
PLEKHA5 protein, human  0   *Intracellular Signaling Peptides and Proteins. Gene. 2012 Jan 15;492(1):270-5
Erp44 protein, rat  0   *Intracellular Signaling Peptides and Proteins. Gend Med. 2011 Oct;8(5):325-33.
WDR26 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. J Biol Chem. 2011 Dec 23;286(51):43902-12.
DSH-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Intracellular Signaling Peptides and Proteins. PLoS Genet. 2010 Aug 12;6(8). pii: e1001056.
PRKL-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Intracellular Signaling Peptides and Proteins Nerve Tissue Proteins. PLoS Genet. 2011 Sep;7(9):e1002257.
TRIL protein, human  0   *Intracellular Signaling Peptides and Proteins. J Biol Chem. 2011 Nov 4;286(44):38795-804.
BlaR1 protein, Staphylococcus aureus  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases Membrane Proteins Intracellular Signaling Peptides and Proteins. Antimicrob Agents Chemother. 1993 May;37(5):1144-9.
Shoc2 protein, rat  0   *Intracellular Signaling Peptides and Proteins. Stem Cells. 2011 Feb;29(2):320-31.
Sufu protein, Xenopus  0   *Xenopus Proteins *Intracellular Signaling Peptides and Proteins. Dev Biol 2011 Oct 1;358(1):262-76
Wbp2 protein, Drosophila  0   *Drosophila Proteins *Intracellular Signaling Peptides and Proteins. Cell Death Differ 2011 Aug;18(8):1346-55
N-rich protein, Arabidopsis  0   *Arabidopsis Proteins *Intracellular Signaling Peptides and Proteins. Plant Physiol Biochem 2011 Mar;49(3):293-302
VarS protein, Vibrio cholerae  EC 2.7.-   *Protein Kinases *Intracellular Signaling Peptides and Proteins. Microb Pathog 2010 Jun;48(6):245-50
Wls protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Nature. 2011 Jun 23;474(7352):511-5
Erbb3b protein, zebrafish  0   *Zebrafish Proteins *Intracellular Signaling Peptides and Proteins. Biochem Biophys Res Commun 2011 Jun 10;409(3):454-8
TGF-beta receptor associated protein-1, mouse  0   *Intracellular Signaling Peptides and Proteins. Immunobiology 2011 Mar;216(3):343-50
TIPE1 protein, human  0   *Intracellular Signaling Peptides and Proteins Tumor Necrosis Factor-alpha. Mol Immunol. 2011 Jul;48(12-13):1548-55
TIPE1 protein, mouse  0   *Intracellular Signaling Peptides and Proteins Tumor Necrosis Factor-alpha. Mol Immunol. 2011 Jul;48(12-13):1548-55
Mtus1 protein, rat  0   *Intracellular Signaling Peptides and Proteins. Biosci Biotechnol Biochem 2011;75(3):414-8
numb protein, rat  0   *Intracellular Signaling Peptides and Proteins. Int J Biol Sci 2011;7(3):269-78
ARGLU1 protein, human  0   *Intracellular Signaling Peptides and Proteins. J Biol Chem 2011 May 20;286(20):17746-54
PDCD10 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. J Clin Invest 2011 May 2;121(5):1871-81
thymocyte-expressed molecule involved in selection, human  0   *Intracellular Signaling Peptides and Proteins. J Biol Chem 2011 Mar 4;286(9):7535-47
anamorsin protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Biochem Biophys Res Commun 2011 Feb 11;405(2):303-7
LIM mineralization protein-3, human  0   *Intracellular Signaling Peptides and Proteins *LIM Domain Proteins. Gene Expr. 2010;15(1):27-42
Mical protein, zebrafish  0   *Cytoskeletal Proteins *Zebrafish Proteins *Intracellular Signaling Peptides and Proteins. J Genet Genomics. 2010 Oct;37(10):685-93
inversin protein, Xenopus  0   *Xenopus Proteins *Intracellular Signaling Peptides and Proteins. Proc Natl Acad Sci U S A 2010 Nov 23;107(47):20388-93
Slam protein, Drosophila  0   *Drosophila Proteins *Intracellular Signaling Peptides and Proteins. Mech Dev 2010 Jul-Aug;127(7-8):371-84
eye transformer protein, Drosophila  0   *Drosophila Proteins *Intracellular Signaling Peptides and Proteins. FASEB J 2010 Nov;24(11):4467-79
DDIP protein, human  0   *Intracellular Signaling Peptides and Proteins. Cell Signal 2010 Nov;22(11):1753-60
sprouty3 protein, Xenopus  0   *Xenopus Proteins *Intracellular Signaling Peptides and Proteins. Development 2010 Dec;137(23):4005-15
sprouty3 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Development 2010 Dec;137(23):4005-15
TIPE2 protein, rat  0   *Intracellular Signaling Peptides and Proteins. Biochim Biophys Acta. 2010 Nov;1802(11):1078-86
NLRP12 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. J Immunol 2010 Oct 15;185(8):4515-9
rundataxin protein, human  0   *Intracellular Signaling Peptides and Proteins. Brain 2010 Aug;133(Pt 8):2439-47
PHLDB1 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. J Biol Chem 2010 Sep 3;285(36):27581-9
TIPE2 protein, human  0   *Intracellular Signaling Peptides and Proteins. Mol Immunol. 2010 Sep;47(15):2435-42
WWTR1 protein, human  0   *Intracellular Signaling Peptides and Proteins.
lipid storage droplet protein 5, mouse  0   *Muscle Proteins *Intracellular Signaling Peptides and Proteins Membrane Proteins. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 May;26(5):438-9
spred1 protein, Danio rerio  0   *Membrane Proteins *Zebrafish Proteins *Intracellular Signaling Peptides and Proteins. Nature. 2010 Apr 22;464(7292):1196-200
APCDD1 protein, human  0   *Membrane Proteins *Intracellular Signaling Peptides and Proteins. Nature 2010 Apr 15;464(7291):1043-7
Chl protein, zebrafish  0   *Zebrafish Proteins *Intracellular Signaling Peptides and Proteins. Dev Biol 2010 May 15;341(2):444-58
NLRC5 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Cell. 2010 Apr 30;141(3):483-96
Pteg protein, Xenopus  0   *Xenopus Proteins *Intracellular Signaling Peptides and Proteins. Mech Dev 2010 Jan-Feb;127(1-2):49-61
GPR177 protein, rat  0   *Receptors, G-Protein-Coupled *Intracellular Signaling Peptides and Proteins. BMC Neurosci. 2010;11() (dup#18):33
GPR177 protein, human  0   *Receptors, G-Protein-Coupled *Intracellular Signaling Peptides and Proteins. BMC Neurosci. 2010;11() (dup#18):33
WDFY4 protein, human  0   *Intracellular Signaling Peptides and Proteins. PLoS Genet. 2010;6(2) (dup#2):e1000841
Pigs protein, Drosophila  0   *Drosophila Proteins *Intracellular Signaling Peptides and Proteins. Development 2010 Mar;137(6):913-22
DSCR1 protein, rat  0   *Intracellular Signaling Peptides and Proteins. Hum Mol Genet 2010 Feb 1;19(9):468-79
NLRC5 protein, human  0   *Intracellular Signaling Peptides and Proteins. J Immunol 2010 Feb 15;184(4):1990-2000
NDL1 protein, Arabidopsis  0   *Arabidopsis Proteins *Intracellular Signaling Peptides and Proteins. Plant Cell 2009 Nov;21(11):3591-609
Wsb-2 protein, human  0   *Intracellular Signaling Peptides and Proteins. Biochem Biophys Res Commun 2010 Feb 5;392(2):171-7
Rim8 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Intracellular Signaling Peptides and Proteins. Mol Cell Biol 2010 Feb;30(4):897-907
girdin -like protein, Drosophila  0   *Drosophila Proteins *Intracellular Signaling Peptides and Proteins. Exp Cell Res 2009 Nov 15;315(19):3370-80
BCL9 protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Dev Biol 2009 Nov 1;335(1):93-105
Gpr177 protein, mouse  0   *Receptors, G-Protein-Coupled *Intracellular Signaling Peptides and Proteins. Proc Natl Acad Sci U S A 2009 Nov 3;106(44):18598-603
Fuz protein, mouse  0   *Intracellular Signaling Peptides and Proteins. Nat Cell Biol 2009 Oct;11(10):1225-32
C1QTNF5 protein, rat  0   *Intracellular Signaling Peptides and Proteins. J Biol Chem 2009 Oct 9;284(41):27780-9
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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