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Benzoxazines

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Definition: OXAZINES with a fused BENZENE ring.  do not confuse with benzoxazolines (index BENZOXAZOLES)    Other names Benzoxazinoids; Benzoxazinones
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3,4-dihydro-3-(2'-hydroxyethylene)-6-methoxy-2H-benzoxazine  0   *Benzoxazines. Molecules. 2012;17(1) (dup#13):511-26
3,4-dihydro-3-(2'-hydroxyethylene)-6-ethyl-2H-benzoxazine  0   *Benzoxazines. Molecules. 2012;17(1) (dup#13):511-26
3,4-dihydro-3-(2'-hydroxyethylene)-6-methyl-2H-benzoxazine  0   *Benzoxazines. Molecules. 2012;17(1) (dup#13):511-26
4-methyl-1-((5-((3-oxo-3,4-dihydro-2H-benzo(1,4)oxazin-6-ylmethyl)carbamoyl)pyrazolo(1,5-a)pyrimidine-7-carbonyl)amino)indan-5-carboxylic acid  0   *Indans *Benzoxazines Matrix Metalloproteinase 13/antagonists & inhibitors. J Med Chem. 2012 Jan 26;55(2):709-16.
KRP-109  0   *Pyrrolidines *Benzoxazines Leukocyte Elastase/antagonists & inhibitors. Pulm Pharmacol Ther. 2011 Dec;24(6):660-5.
SPA0355  0   *Benzoxazines Thiourea/*analogs & derivatives. Br J Pharmacol. 2011 Sep;164(2b):794-806.
6-(1-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)-2H-1,4-benzoxazin-3(4H)-one  0   *Pyrazoles *Benzoxazines Receptors, Mineralocorticoid/antagonists & inhibitors. J Med Chem. 2011 Dec 22;54(24):8616-31.
8-hydroxyefavirenz  0   *Benzoxazines. J Antimicrob Chemother. 2011 Oct;66(10):2350-61
AZ 505  0   *Benzoxazines beta-Alanine/*analogs & derivatives Histone-Lysine N-Methyltransferase/antagonists & inhibitors. Structure. 2011 Sep 7;19(9):1262-73.
N-4,4-dimethyl-2-thioxo-1,4-dihydro-2H-3,1-benzoxazin-6-ylthiophene-2-sulfonamide  0   *Sulfonamides *Benzoxazines Receptors, Mineralocorticoid/antagonists & inhibitors. J Pharmacol Sci 2011;115(3):346-53
benzoxacystol  0   *Benzoxazines. J Antibiot (Tokyo). 2011 Jun;64(6):453-7
4'-(1-(((6,7-dichloro-3- oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(4-morpholinyl)ethyl)-4-biphenylcarboxylic acid  0   *Benzoic Acids *Benzoxazines. Br J Pharmacol 2010 Sep;161(1):207-28
4'-(1-(((6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(1-pyrrolidinyl)ethyl)-3-biphenylcarboxamide  0   *Benzamides *Benzoxazines. Br J Pharmacol 2010 Sep;161(1):207-28
2-(2,6-difluorophenyl)-4a,5,6,7,8,8a-hexahydro-4a-(4-methoxyphenyl)-4H-benzo(e)(1,3)oxazine  0   *Benzoxazines. Cancer Lett. 2010 Nov 28;297(2):231-43
N-(1-(3-(3-oxo-2,3-dihydrobenzo(1,4)oxazin-4-yl)propyl)piperidin-4-yl)-2-phenylacetamide  0   *Benzeneacetamides *Benzoxazines Receptor, Muscarinic M1/agonists. J Med Chem 2010 Sep 9;53(17):6386-97
6-amino-2-(3',5'-dibromo-4'-hydroxybenzylidene)-2H-benzo(b)(1,4)oxazin-3-(4H)-one  0   *Benzoxazines. J Neurosci Res 2010 Jul;88(9):1970-84
6-(2-(4-(2-methyl-5-quinolinyl)-1-piperazinyl)ethyl)-4H-imidazo(5,1-c)(1,4)benzoxazine-3-carboxamide  0   *Benzoxazines Receptor, Serotonin, 5-HT1A Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D. J Med Chem 2010 Aug 12;53(15):5827-43
olodaterol  0   *Benzoxazines. Bioorg Med Chem Lett 2010 Feb 15;20(4):1410-4
1-(3-(3-(4-acetylpiperazin-1-yl)propyl)-7-fluoro-3-phenyl-3a,4-dihydro-3H-pyrazolo(5,1-c)(1,4)benzoxazin-2-yl)ethanone  0   *Pyrazoles *Benzoxazines. Biochem Pharmacol 2010 May 15;79(10):1526-333
N(4)-((2,2-difluoro-4H-benzo(1,4)oxazin-3-one)-6-yl)-5-fluoro-N(2)-(3-(methylaminocarbonylmethyleneoxy)phenyl)-2,4-pyrimidinediamine  0   *Pyrimidines *Benzoxazines. Expert Opin Ther Pat 2009 Oct;19(10):1469-72
CX 3543  0   *Quinolones *Benzoxazines. Cancer Res 2009 Oct 1;69(19):7653-61
resorufin glucopyranoside  0   *Glucosides *Benzoxazines. Anal Biochem 2009 Jul 1;390(1):79-84
6-(9-(diethylamino)-5-oxo-5 H-benzo(alpha)phenoxazin-2-yloxy)hex-2-enyl acetate  0   *Benzoxazines. Chembiochem. 2009 May 4;10(7):1200-7
6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine  0   *Benzoxazines. Bioorg Med Chem Lett 2009 May 15;19(10):2896-900
4-(2-diethylaminoacetyl)-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo(1,4)oxazine-2-carboxylic acid ethyl ester  0   *Benzoxazines. J Med Chem 2009 Apr 23;52(8):2328-40
2-diethylamino-1-(5,7,8-trimethyl-2-phenyl-2,3-dihydro-benzo(1,4)oxazin-4-yl)-ethanone  0   *Benzoxazines. J Med Chem 2009 Apr 23;52(8):2328-40
cephalandole A  0   *Indoles *Benzoxazines Alkaloids. J Nat Prod. 2008 Aug;71(8):1447-50
(2R)-2-O-beta-D-glucopyranosyl-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one  0   *Benzoxazines. J Chromatogr A. 2008 Sep 26;1205(1-2):177-81
(2R)-2-O-beta-D-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one  0   *Benzoxazines. J Chromatogr A. 2008 Sep 26;1205(1-2):177-81
10-(3-cyclopropylaminomethyl-4-fluoro-1-pyrrolidinyl)-9-fluoro-3-fluoromethyl-2,3-dihydro-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid  0   *Quinolones *Benzoxazines. J Med Chem 2008 Jun 12;51(11):3238-49
3-(benzyl(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino)-3-oxopropanoic acid  0   *Benzoxazines. J Med Chem 2008 May 8;51(9):2863-7
2-(N phthaloylmethyl)-4H-3,1-benzoxazin-4-one  0   *Benzoxazines. Molecules. 2004;9(8):705-12
10-(1-(dimethylamino)ethyl)-1,4a,5,7,7a,9,9a,10,11,12,12a,12b,13,14,14a,14b-hexadecahydro-11-hydroxy-9a,12,a,14b-trimethyl-3-(1-methylethyl)-8H-indeno(5',4'-4,5)cyclohepta(1,2-f)(3,1)benzoxazin-8-one  0   *Triterpenes *Benzoxazines. J Med Chem 2007 Nov 1;50(22):5311-23
EMD478761  0   *Benzoxazines. Invest Ophthalmol Vis Sci 2007 Nov;48(11):5184-90
6-bromo-3-(4-butylphenyl)-1,3-benzoxazine-2,4-(3H)-dione  0   *Benzoxazines. Arch Pharm (Weinheim) 2007 May;340(5):264-7
cetilistat  282526-98-1   *Benzoxazines. Int J Obes (Lond) 2007 Mar;31(3):494-9
6-chloro-2-propyl-3-(pyrid-3-ylamino)-2H-1,4-benzoxazine  0   *Aminopyridines *Benzoxazines. Br J Pharmacol 2006 Dec;149(7):70-9
4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one  0   *Benzoxazines Receptor, Muscarinic M1/agonists. Mol Pharmacol 2006 Dec;70(6):1974-83
URB 754  0   *Aniline Compounds *Benzoxazines. Nat Neurosci 2005 Sep;8(9):1139-41
3a-acetoxy-5H-pyrrolo(1,2-a)(3,1)benzoxazin-1,5-(3aH)-dione  0   *Pyrroles *Benzoxazines. J Enzyme Inhib Med Chem 2006 Apr;21(2):133-8
SB-649915  0   *Piperidines *Quinolines *Benzoxazines. Eur J Pharmacol 2006 Apr 24;536(1-2):54-61
RWJ 348260  0   *Benzoxazines. Diabetes Obes Metab. 2005 Sep;7(5):536-46
2-(2-Br-phenyl)-8-methoxy-benzoxazinone  0   *Benzoxazines. Eur J Pharmacol. 2005 Dec 19;527(1-3):37-43
8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazin-1-yl)-4H-benzo(1,4)oxazin-2-methyl-3-one  0   *Indoles *Benzoxazines Receptors, Dopamine D2/antagonists & inhibitors. J Med Chem 2005 Nov 3;48(22):6855-69
tanaproget  0   *Thiones *Benzoxazines Receptors, Progesterone/agonists. J Biol Chem 2005 Aug 5;280(31):28468-75
tanoproget  0   *Pyrroles *Benzoxazines Receptors, Progesterone/agonists. J Med Chem 2005 Aug 11;48(16):5092-5
2,4-dihydroxy-(2H)-1,4-benzoxazin-3(4H)-one  0   *Benzoxazines. J Agric Food Chem. 2005 Feb 9;53(3):554-61
CJ 12662  0   *Pyrroles *Benzoxazines. J Org Chem 2004 Nov 12;69(23):7875-9
2H-1,4-benzoxazin-3(4H)-one, 6-methoxy-2-methyl-4-carbaldehyde  0   *Aldehydes *Benzoxazines. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2223-5
ZK 216348  0   *Benzofurans *Benzoxazines. Proc Natl Acad Sci U S A 2004 Jan 6;101(1);227-32
7-chloro-(2)-2-O-glucopyranosyl-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one  0   *Glycosides *Benzoxazines. Phytochemistry 2001 Nov;58(5):811-7
2-O-glucopyranosyl-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one  0   *Glucosides *Benzoxazines. Phytochemistry 2001 Oct;58(4):637-40
7-chloro-2-O-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one  0   *Glucosides *Benzoxazines. Phytochemistry 2001 Oct;58(4):637-40
(3-cyclopentyl-8-benzylamino-3,4-dihydro-2H-1,4-benzoxazin-5-yl)phenylmethanone  0   *Benzoxazines. Eur J Pharmacol 2001 Jul 27;424(3):189-94
2-hydroxy-1,4-benzoxazin-3-one  0   *Benzoxazines. Phytochemistry 2001 Jun;57(3):373-6
3-(2-(1-(1,3-dioxolan-2-ylmethyl)-4-piperidyl)ethyl)-2H-3,4-dihydro-1,3-benzoxazin-2,4-dione hydrochloride  0   *Piperidines *Benzoxazines. Eur J Pharmacol 2001 Mar 16;415(2-3):157-64
2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one glucoside  0   *Glucosides *Benzoxazines. Phytochemistry 2001 Apr;56(7):669-75
2-O-glucopyranosyl-4-hydroxy-7-methoxy-1,4-benzoxazin-3-one  0   *Glucosides *Benzoxazines. Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13555-60
3-(4-(5-(2,6-dimethyltetrahydro-1(2H)-pyridinyl)pentyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-1-benzenecarboximidamide  0   *Amidines *Benzoxazines Factor Xa/antagonists & inhibitors. J Med Chem 2000 Nov 2;43(22):4063-70
2-(4-biphenyl)-4-methyl-octahydro-1,4-benzoxazin-2-ol  0   *Biphenyl Compounds *Benzoxazines. J Med Chem 2000 Feb 24;43(4):609-12
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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