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14-3-3 Proteins

More information in Books or onNLM PubMed
Definition: A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.      Other names eta Protein, 14-3-3; Protein, 14-3-3tau; Brain 14 3 3 Protein; 14-3-3 Protein, Brain; 14 3 3zeta Protein; 14 3 3tau Protein; 14 3 3gamma Protein; 14 3 3eta Protein; 14 3 3epsilon Protein; 14 3 3beta Protein; 14 3 3 zeta Protein; 14 3 3 tau Protein; 14 3 3 gamma Protein; 14 3 3 eta Protein; 14 3 3 epsilon Protein; 14 3 3 beta Protein; 14 3 3 Proteins; 14 3 3 Protein, zeta Isoform; 14 3 3 Protein, tau Isoform; 14 3 3 Protein, gamma Isoform
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BV02 compound  0   *Benzamides *Pyrazoles 14-3-3 Proteins/antagonists & inhibitors. J Pharmacol Exp Ther 2011 Mar;336(3):596-604
14-3-3kappa protein, Arabidopsis  0   *Arabidopsis Proteins *14-3-3 Proteins. FEBS Lett 2011 Jan 3;585(1):143-7
14-3-3chi protein, Arabidopsis  0   *Arabidopsis Proteins *14-3-3 Proteins. FEBS Lett 2011 Jan 3;585(1):143-7
14-3-3 lambda protein, Arabidopsis  0   *Arabidopsis Proteins *14-3-3 Proteins. FEBS Lett 2009 Jul 7;583(13):2187-93
R18 peptide  0   *Peptides 14-3-3 Proteins/antagonists & inhibitors. Biochemistry 1999 Sep 21;38(38):12499-504
Sfn protein, rat  0   *14-3-3 Proteins. Endocrinology. 2007 May;148(5):2037-44
14-3-3omega protein, Arabidopsis  0   *Arabidopsis Proteins *14-3-3 Proteins. Plant J 2003 May;34(4):473-84
GRF5 protein, Arabidopsis  0   *Trans-Activators *14-3-3 Proteins. Proc Natl Acad Sci U S A 2004 Sep 7;101(36):13374-9
Sfn protein, mouse  0   *14-3-3 Proteins. Biol Reprod 2004 Dec;71(6):1870-8
Ywhaz protein, rat  0   *Molecular Chaperones *14-3-3 Proteins.
YWHAH protein, human  0   *14-3-3 Proteins.
YWHAE protein, human  0   *14-3-3 Proteins.
YWHAB protein, human  0   *14-3-3 Proteins.
par-5 protein, C elegans  0   *Caenorhabditis elegans Proteins *14-3-3 Proteins.
SFN protein, human  EC 3.1.-   *Exonucleases *Tumor Markers, Biological *14-3-3 Proteins. Cell Growth Differ. 1992 Aug;3(8):507-13.; J Biol Chem 2000 Aug 25;275(34):25900-6
AFT1 protein, Arabidopsis  0   *Arabidopsis Proteins *14-3-3 Proteins. Biochim Biphys Acta 1995 Apr 6;1266(1):113-6
BMH2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *14-3-3 Proteins. Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11539-43
BMH1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins 14-3-3 Proteins. FEBS Lett 1992 May 11;302(2):145-50

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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