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ATP-Dependent Proteases

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Definition: Proteases that contain proteolytic core domains and ATPase-containing regulatory domains. They are usually comprised of large multi-subunit assemblies. The domains can occur within a single peptide chain or on distinct subunits.     
Examples ATP-Dependent Endopeptidases 		Other names Proteases, ATP-Dependent; Protease, ATP-Requiring; Protease, ATP-Dependent; Adenosine Triphosphate Dependent Proteolytic Syste; ATP Requiring Protease; ATP Dependent Proteases; ATP Dependent Protease; Adenosine Triphosphate-Dependent Proteolytic Syste; ATP-Requiring Protease; ATP-Dependent Protease
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Afg3l2 protein, mouse  EC 3.4.24.-   *ATP-Dependent Proteases. Hum Mol Genet 2009 Jun 1;18(11):2001-13
FtsH8 protein, Arabidopsis  EC 3.4.21.-   *Arabidopsis Proteins *ATP-Dependent Proteases. J Biol Chem 2006 Aug 4;281(31):21660-9
FtsH protein, E coli  EC 3.4.21.-   *Escherichia coli Proteins *ATP-Dependent Proteases.
VAR2 protein, Arabidopsis  EC 3.4.21.-   *Membrane Proteins *Arabidopsis Proteins *ATP-Dependent Proteases. Plant Mol Biol 1999 Oct;41(3):321-37
AFG3L2 protein, human  EC 3.4.24.-   *ATP-Dependent Proteases. Genomics 1999 Jul 1;59(1):51-8
mitochondrial intermembrane space protease  EC 3.4.21.-   *ATP-Dependent Proteases. Biochem Mol Biol Int 1995 Jul;36(4):871-81
PIM1 protein, S cerevisiae  EC 3.4.21.-   *Serine Endopeptidases *Mitochondrial Proteins *Saccharomyces cerevisiae Proteins *ATP-Dependent Proteases. J Biol Chem 1994 Jan 7;269(1):238-42
YME1 protein, S cerevisiae  EC 3.4.21.-   *Saccharomyces cerevisiae Proteins *ATP-Dependent Proteases. Mol Cell Biol 1993 Sep;13(9):5418-26

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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