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Dioxygenases
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Definition
: Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
Examples
Catechol 1,2-Dioxygenase
;
Catechol 2,3-Dioxygenase
;
Cysteine Dioxygenase
;
Homogentisate 1,2-Dioxygenase
;
3-Hydroxyanthranilate 3,4-Dioxygenase
;
4-Hydroxyphenylpyruvate Dioxygenase
;
Indoleamine-Pyrrole 2,3,-Dioxygenase
;
Jumonji Domain-Containing Histone Demethylases
;
Lipoxygenases
;
Protocatechuate-3,4-Dioxygenase
;
Tryptophan Oxygenase
Substance
CAS Registry & name
Categories
Source
Drugs
*
ALKBH8 protein, Arabidopsis
EC 1.13.11.-
*Arabidopsis Proteins
*Dioxygenases.
Nucleic Acids Res. 2011 Sep 1;39(17):7688-701
ALKBH5 protein, human
EC 1.14.11.-
*Membrane Proteins
*Dioxygenases.
PLoS One 2011;6(1):e16210
HIF prolyl hydroxylase, rat
EC 1.14.11.2
*Dioxygenases.
J Neurochem. 2010 Oct;115(1):209-19
o-
xylene dioxygenase, Rhodococcus
EC 1.13.11.-
*Bacterial Proteins
*Dioxygenases.
Appl Microbiol Biotechnol. 2010 May;86(6):1841-7
ETHE1 protein, mouse
EC 1.13.11.18
*Mitochondrial Proteins
*Dioxygenases.
Nat Med 2009 Feb;15(2):200-5
At2g25450 protein, Arabidopsis
EC 1.14.99.-
*Dioxygenases
*Arabidopsis Proteins.
Plant Physiol 2008 Dec;148(4):2096-108
hydroxymandelate synthase, Amycolatopsis orientalis
EC 1.13.11.-
*Dioxygenases.
Biochemistry 2008 Feb 19;47(7):2002-13
2'-
aminobiphenyl-
2,3-
diol-
1,2-
dioxygenase, Pseudomonas stutzeri
EC 1.13.11.-
*Dioxygenases.
Cell Biochem Biophys 2006;44(3):530-8
salicylate 1,2-
dioxygenase, Pseudaminobacter salicylatoxidans
EC 1.13.11.-
*Dioxygenases.
Acta Crystallograph Sect F Struct Biol Cryst Commun 2006 Jun 1;62(Pt 6):553-5
ABH3 protein, mouse
EC 1.14.11.-
*DNA Repair Enzymes
*Dioxygenases.
EMBO J 2006 May 17;25(10):2189-98
Alkbh2 protein, mouse
EC 1.14.11.-
*DNA Repair Enzymes
*Dioxygenases.
EMBO J 2006 May 17;25(10):2189-98
ADI1 protein, S cerevisiae
EC 1.13.11.-
*Saccharomyces cerevisiae Proteins
*Dioxygenases.
J Biol Chem 2005 Aug 12;280(32):28997-9003
xanthine dioxygenase, Aspergillus nidulans
EC 1.14.11.-
*Fungal Proteins
*Dioxygenases.
Mol Microbiol 2005 Jul;57(1):276-90
indole dioxygenase idoA, Pseudomonas alcaligenes
EC 1.13.11.17
*Dioxygenases.
FEMS Microbiol Lett 2004 Oct 15;239(2):285-93
CCD8 protein, Arabidopsis
EC 1.13.11.-
*Arabidopsis Proteins
*Dioxygenases.
J Biol Chem 2004 Nov 5;279(45):46940-5
CCD7 protein, Arabidopsis
EC 1.13.11.-
*Dioxygenases.
J Biol Chem 2004 Nov 5;279(45):46940-5
EGLN3 protein, human
EC 1.14.11.2
*Dioxygenases.
FEBS Lett 2004 Jul 16;570(1-3):166-70
ALKBH2 protein, human
0
*DNA Repair Enzymes
*Dioxygenases
DNA Repair.
Nucleic Acids Res 2004;32(4):1548-54
ALKBH3 protein, human
EC 1.14.11.-
*Dioxygenases
*DNA Repair Enzymes
DNA Repair.
Nucleic Acids Res 2004;32(4):1548-54
ADI1 protein, human
EC 1.-
*Dioxygenases.
J Biol Chem 2004 Mar 26;279(13):12734-43
Adi1 protein, rat
EC 1.13.11.-
*Dioxygenases.
Endocrinology 2004 Apr;145(4):1933-42
sulfur dioxygenase
EC 1.13.11.18
*Dioxygenases.
Microbiology 2003 Jul;149(Pt 7):1699-709
EGLN2 protein, human
EC 1.14.11.-
*Nuclear Proteins
*Dioxygenases.
Oncogene 2002 Jan 24;21(5):836-43
carotenoid cleavage dioxygenase 1
EC 1.13.11.-
*Dioxygenases.
J Biol Chem 2001 Jul 6;276(27):25208-11
dibenzofuran 4,4a-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
Biochem Biophys Res Commun 2001 Apr 27;283(1):195-204
2,4'-
dihydroxyacetophenone dioxygenase
EC 1.13.11.41
*Dioxygenases.
Biochem J 1999 Dec 1;344( Pt 2):397-402
JLP1 protein, S cerevisiae
EC 1.14.11.-
*Saccharomyces cerevisiae Proteins
*Dioxygenases.
J Bacteriol 1999 Sep;181(18):5876-9
flavonol 2,4-
dioxygenase
EC 1.13.11.-
*Dioxygenases
Copper
Glycoproteins
Flavonols.
2,6-
dichlorohydroquinone dioxygenase
EC 1.13.-
*Dioxygenases.
Biochemistry 1999 Jun 15;38(24):7659-69
DitA protein, Pseudomonas abietaniphila
EC 1.13.11.-
*Ferredoxins
*Dioxygenases.
J Bacteriol 1999 May;181(9):2675-82
1-
hydroxy-
2-
naphthoate dioxygenase
EC 1.13.11.-
*Dioxygenases.
J Biol Chem 1998 Apr 3;273(14):8332-6
9-
cis-
epoxy-
carotenoid dioxygenase
EC 1.13.11.51
*Plant Proteins
*Dioxygenases
Chloroplasts
Arabidopsis Proteins.
Proc Natl Acad Sci U S A 1997 Oct 28;94(22):12235-40
carbazole 1,9a-
dioxygenase
EC 1.13.11.-
*Bacterial Proteins
*Dioxygenases.
J Bacteriol 1997 Aug;179(15):4850-8
2-
aminophenol 1,6-
dioxygenase
EC 1.13.-
*Dioxygenases.
J Biol Chem 1997 Jun 6;272(23):14727-32
1H-
3-
hydroxy-
4-
oxoquinaldine 2,4-
dioxygenase (decyclizing, CO-
forming)
EC 1.13.11.-
*Dioxygenases.
Eur J Biochem 1996 Sep 15;240(3):576-83
1H-
3-
hydroxy-
4-
oxoquinoline 2,4-
dioxygenase (decyclizing, CO-
forming)
EC 1.13.11.-
*Dioxygenases.
Eur J Biochem 1996 Sep 15;240(3):576-83
YHB1 protein, S cerevisiae
EC 1.14.12.17
*Hemeproteins
*Saccharomyces cerevisiae Proteins
*Dioxygenases.
Proc Natl Acad Sci U S A 1992 Jun 1;89(11):5015-9
6-
chlorohydroxyquinol 1,2-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
J Bacteriol 1995 Jan;177(1):229-34
pahA protein, Pseudomonas putida
EC 1.13.11.-
*Bacterial Proteins
*Dioxygenases.
J Bacteriol 1994 Apr;176(8):2444-9
3-
chlorobenzoate-
3,4-
(4,5)-
dioxygenase
EC 1.14.-
*Dioxygenases
Alcaligenes.
Appl Environ Microbiol 1993 Nov;59(11):3625-33
2,2',3-
trihydroxybiphenyl dioxygenase
EC 1.13.11.-
*Dioxygenases.
J Bacteriol 1993 Nov;175(22):7313-20
aci-
reductone oxidase (CO-
forming)
EC 1.13.11.-
*Dioxygenases.
J Biol Chem 1993 Oct 15;268(29):21466-9
3-
carboxyethylcatechol 2,3-
dioxygenase
EC 1.13.11.16
*Dioxygenases.
Biochim Biophys Acta 1993 Oct 6;1202(2):258-64
3,5-
dichlorocatechol 1,2-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
Arch Biochem Biophys 1993 Feb 1;300(2):738-46
2,3-
dihydroxy-
4-
cumate-
3,4-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
Biochem Int 1992 Oct;28(1):97-103
2,3-
dihydroxybiphenyl oxygenase
EC 1.13.11.39
*Dioxygenases.
J Bacteriol 1983;154(3):1356
5-
aminosalicylic acid 1,2-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
Biochem J 1992 Mar 15;282(Pt 3):675-80
3,4-
dihydroxyxanthone dioxygenase
EC 1.13.11.-
*Dioxygenases
Xanthones.
Appl Environ Microbiol 1991;57(8):2217
chlorobenzene dioxygenase
EC 1.13.99.-
*Dioxygenases.
J Bacteriol 1991;173(22):7077
lignostilbene-
alpha,beta-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
Agric Biol Chem 1991;55(5):1411
4-
sulfobenzoate 3,4-
dioxygenase
EC 1.14.12.-
*Dioxygenases.
Biochem J 1991;274(Pt 3):833
protocatechuate 2,3-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
Methods Enzymol 1990;188:95
3-
phenylcatechol dioxygenase
EC 1.13.11.-
*Dioxygenases.
Appl Environ Microbiol 1988;54(11):2664
3-
methylcatechol 2,3-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
Appl Environ Microbiol 1988;54(6):1498
catechol oxygenase II
EC 1.13.11.-
*Dioxygenases.
Proc Natl Acad Sci USA 1987;84(13):4460
(4-
hydroxybenzoyl)methanol dioxygenase
EC 1.13.11.-
*Dioxygenases.
Biochem J 1986;239(2):469
isopropylbenzene dioxygenase
EC 1.13.11.-
*Dioxygenases.
J Bacteriol 1986;168(1):123
chlorocatechol 1,2-
dioxygenase
EC 1.13.11.-
*Dioxygenases
Bacterial Proteins.
J Bacteriol 1985;161(1):85
4-
chlorophenylacetate 3,4-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
J Bacteriol 1984;160(2):618
hydroxyquinol 1,2-
dioxygenase
EC 1.13.11.-
*Dioxygenases.
J Bacteriol 1984;159(1):353
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