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Transient Receptor Potential Channels

More information in Books or onNLM PubMed
Definition: A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.  note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN   
Examples TRPC Cation Channels; TRPM Cation Channels; TRPP Cation Channels; TRPV Cation Channels 		Other names Membrane Proteins, TRP; Channels, TRP Cation; Cation Channels, TRP; TRP Membrane Proteins; TRP Cation Channels; Proteins, TRP Membrane
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
A 967079  0   *Oximes Analgesics, Non-Narcotic Transient Receptor Potential Channels/antagonists & inhibitors. Pain 2011 May;152(5):1165-72
dibenzo(b,f)(1,4)oxazepine-4-carboxylic acid methyl ester  0   *Oxazepines Transient Receptor Potential Channels/agonists. J Med Chem 2010 Oct 14;53(19):7011-20
5H-dibenzo(b,e)azepine-10-carboxylic acid methyl ester  0   *Dibenzazepines Transient Receptor Potential Channels/agonists. J Med Chem 2010 Oct 14;53(19):7011-20
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide  0   *Acetanilides *Purines Transient Receptor Potential Channels/antagonists & inhibitors. Mol Pain 2008 Oct 27;4:48
water witch protein, Drosophila  0   *Drosophila Proteins *Transient Receptor Potential Channels. Nature 2007 Nov 8;450(7167):294-8
Mcoln1 protein, mouse  0   *Transient Receptor Potential Channels Mucolipidoses. J Biol Chem 2006 Jun 23;281(25):17517-27
MCOLN3 protein, human  0   *Transient Receptor Potential Channels. Pflugers Arch 2005 Oct;451(1):277-85
Mcoln2 protein, human  0   *Transient Receptor Potential Channels. Pflugers Arch 2005 Oct;451(1):277-85
Mcoln2 protein, mouse  0   *Transient Receptor Potential Channels. Cell Immunol 2005 May;235(1):46-55
nanchung protein, Drosophila  0   *Drosophila Proteins *Transient Receptor Potential Channels. Nature 2003 Jul 3;424(6944):81-4
Trpa1 protein, mouse  0   *Transient Receptor Potential Channels. Nature 2003 Jun 19;423(6942):822-3
trpn1 protein, zebrafish  0   *Zebrafish Proteins *Transient Receptor Potential Channels. Science 2003 Jul 4;301(5629):96-9
TRPA1 protein, human  0   *Nerve Tissue Proteins *Calcium Channels *Transient Receptor Potential Channels Nociceptors. Cell 2003 Mar 21;112(6):819-29
Mcoln3 protein, mouse  0   *Transient Receptor Potential Channels. Proc Natl Acad Sci U S A 2002 Nov 12;99(23):14994-9
MCOLN1 protein, human  0   *Transient Receptor Potential Channels Mucolipidoses. Am J Hum Genet 2000 Nov;67(5):1110-20; Nat Genet 2000 Sep;26(1):118-21
TRPgamma protein, Drosophila  0   *Drosophila Proteins *Transient Receptor Potential Channels. Neuron 2000 Jun;26(3):647-57
NOMPC protein, Drosophila  0   *Drosophila Proteins *Transient Receptor Potential Channels. Science 2000 Mar 24;287(5461):2229-34
OSM-9 protein, C elegans  0   *Nerve Tissue Proteins *Caenorhabditis elegans Proteins *Transient Receptor Potential Channels. J Neurosci 1997 Nov 1;17(21):8259-69
trpl protein, Drosophila  0   *Drosophila Proteins *Transient Receptor Potential Channels. Neuron 1992 Apr;8(4):631-42
trp protein, Drosophila  0   *Drosophila Proteins *Transient Receptor Potential Channels. Neuron 1989;3(1):81

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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