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Metabolic Detoxication, Phase II

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Definition: Conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.     
See Also Protein Processing, Post-Translational 		Other names Phase II Detoxifications; Metabolic Detoxications, Conjugative; Detoxifications, Phase II; Detoxications, Conjugative Metabolic; Detoxication, Conjugative Metabolic; Conjugative Metabolic Detoxications; Conjugative Metabolic Detoxication; Phase II Detoxification; Metabolic Detoxification, Phase II; Detoxification, Phase II; Metabolic Detoxication, Conjugative

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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