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Norepinephrine Plasma Membrane Transport Proteins

More information in Books or onNLM PubMed
Definition: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.      Other names Transporters, Noradrenaline-Specific Neurotransmit; Transporter, Norepinephrine; Transporter, Noradrenaline; Transporter Protein, Norepinephrine; Sodium Dependent Noradrenaline Transporter; Noradrenaline-Specific Neurotransmitter Transporte; Noradrenaline Transporter, Sodium-Dependent; Neurotransmitter Transporters, Noradrenaline Speci; Neuronal NET Protein; Sodium-Dependent Noradrenaline Transporter; Norepinephrine Transporter Protein; Norepinephrine Transporter; Noradrenaline Transporter; Noradrenaline Plasma Membrane Transport Proteins; NET Protein, Neuronal; Norepinephrine Plasma Membrane Transporters; Norepinephrine Plasma Membrane Transporter Protein; Neurotransmitter Transporters, Noradrenaline-Speci
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(2-fluorophenyl)-3-(2-(morpholin-2-yl)ethyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide  0   *Cyclic S-Oxides *Thiadiazoles Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors. J Med Chem. 2011 Oct 13;54(19):6824-31.
2-(4-(4-chlorophenyl)-1-methylpiperidin-3-ylmethylsulfanyl)-1-(3-methylpiperidin-1-yl)-ethanone  0   *Piperidines Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors Serotonin Plasma Membrane Transport Proteins. J Pharmacol Exp ther 2010 Dec;335(3):762-70
4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol  0   *Naphthols *Pyrrolidines Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors Histamine H3 Antagonists. J Med Chem 2010 Nov 11;53(21):7869-73
Slc6a2 protein, mouse  0   *Norepinephrine Plasma Membrane Transport Proteins.
SLC6A2 protein, human  0   *Norepinephrine Plasma Membrane Transport Proteins.
Slc6a2 protein, rat  0   *Norepinephrine Plasma Membrane Transport Proteins.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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