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Glycine Plasma Membrane Transport Proteins

More information in Books or onNLM PubMed
Definition: A family of sodium chloride-dependent neurotransmitter symporters that transport the amino acid GLYCINE. They differ from GLYCINE RECEPTORS, which signal cellular responses to GLYCINE. They are located primarily on the PLASMA MEMBRANE of NEURONS; GLIAL CELLS; EPITHELIAL CELLS; and RED BLOOD CELLS where they remove inhibitory neurotransmitter glycine from the EXTRACELLULAR SPACE.     
See Also Glycine Agents; Receptors, Glycine 		Other names Transporters, Glycine-Specific Neurotransmitter; Neurotransmitter Transporters, Glycine Specific; Neurotransmitter Transport Proteins, Glycine Speci; Glycine-Specific Neurotransmitter Transporters; Glycine Transporter 2; Glycine Transporter 1; Glycine Plasma Membrane Transporter Proteins; Glycine Transporter; GLYT Proteins; Neurotransmitter Transporters, Glycine-Specific; Neurotransmitter Transport Proteins, Glycine-Speci
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-chloro-N-((1-methylpiperidin-2-yl)(thiophen-3-yl)methyl)-4-(trifluoromethyl)picolinamide  0   *Thiophenes Niacinamide/*analogs & derivatives Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors. PLoS One 2011;6(6):e21322
1-methyl-1H-imidazole-4-carboxylic acid (3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo(3.1.0) hex-6-ylmethyl)amide  0   *Imidazoles *Azabicyclo Compounds Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors. Neuroreport. 2010 Mar 31;21(5):390-4
((2-chloro-N-(1-(ethylsulfonyl)-4-isobutylpiperidin-4-yl)methyl))-4-(trifluoromethyl)benzamide  0   *Benzamides *Piperidines Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors. Behav Brain Res. 2010 Feb 11;207(1):37-43
ALX 1393  0   Serine/*analogs & derivatives Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors. Neurosci Lett 2008 Nov 21;445(3):214-9
GlyT2 protein, Xenopus  0   *Xenopus Proteins *Glycine Plasma Membrane Transport Proteins. Gene Expr Patterns 2008 Apr;8(4):261-70
GlyT1 protein, Xenopus  0   *Xenopus Proteins *Glycine Plasma Membrane Transport Proteins. Gene Expr Patterns 2008 Apr;8(4):261-70
GlyT2 protein, zebrafish  0   *Zebrafish Proteins *Glycine Plasma Membrane Transport Proteins. J Neurosci 2005 Jul 13;25(28):6610-20
SLC6A9 protein, zebrafish  0   *Zebrafish Proteins *Glycine Plasma Membrane Transport Proteins. J Neurosci 2005 Jul 13;25(28):6610-20
2-chloro-N-((S)-phenyl((2S)-piperidin-2-yl)methyl)-3-trifluoromethyl benzamide  0   *Benzamides *Piperidines Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors. Neuropsychopharmacology. 2005 Nov;30(11):1963-85
SLC6A5 protein, human  0   *Glycine Plasma Membrane Transport Proteins.
Slc6a5 protein, mouse  0   *Glycine Plasma Membrane Transport Proteins.
Slc6a5 protein, rat  0   *Glycine Plasma Membrane Transport Proteins.
SLC6A9 protein, human  0   *Glycine Plasma Membrane Transport Proteins.
Slc6a9 protein, mouse  0   *Glycine Plasma Membrane Transport Proteins.
Slc6a9 protein, rat  0   *Glycine Plasma Membrane Transport Proteins.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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