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Complement C3-C5 Convertases

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Definition: Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue.     
Pharmacological Action Immunologic Factors
Examples Complement C3-C5 Convertases, Alternative Pathway; Complement C3-C5 Convertases, Classical Pathway; Mannose-Binding Protein-Associated Serine Proteases 		Other names Complement 3 Convertase; C5 Convertase; C5 Cleaving Enzyme; C3-C5 Convertase; C3 Activator; C 3 Convertase; C3 Convertase; Convertases, Complement C5; Convertases, Complement C3-C5; Convertases, Complement C3; Convertase, Complement 3; Convertase, C3-C5; Convertase, C3; Convertase, C 3; Complement C3 C5 Convertases; C5 Convertases, Complement; C3-C5 Convertases, Complement; C3 Convertases, Complement; C3 C5 Convertase; Activator, C3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
rosmarinic acid  537-15-5   *Cinnamates *Depsides Aldehyde Reductase/antagonists & inhibitors Complement C3-C5 Convertases/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants ; Platelet Aggregation Inhibitors ; Serine Proteinase Inhibitors 		Arch Pharm (Weinheim) 1984;317(4):339

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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