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Receptors, Dopamine D3

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Definition: A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.  see SCR for organism-specific terms    Other names Receptor, Dopamine D3; Dopamine-D3 Receptor; D3 Receptors, Dopamine; D3 Receptor, Dopamine; Receptor, Dopamine-D3; Dopamine D3 Receptor; Dopamine D3 Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
YQA14  0   *Benzoxazoles *Piperazines Receptors, Dopamine D3/antagonists & inhibitors. Addict Biol. 2012 Mar;17(2):259-73.
N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-3-yl)benzamide  0   *Benzamides *Piperazines Receptors, Dopamine D3/agonists. Neuropharmacology 2011 Feb-Mar;60(2-3):284-94
7-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one  0   *Piperazines *Quinolones Receptors, Dopamine D2/agonists Receptors, Dopamine D3/agonists. Bioorg Med Chem 2011 Jun 1;19(11):3502-11
7-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one  0   *Piperazines *Quinolones Receptors, Dopamine D2/agonists Receptors, Dopamine D3/agonists. Bioorg Med Chem 2011 Jun 1;19(11):3502-11
11-(3-(4-((4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-1H-1,2,3-triazol-1-yl)propoxy)-N-propylnoraporphine  0   *Aporphines *Piperazines Ligands Receptors, Dopamine D3. Bioorg Med Chem 2011 Mar 15;19(6):1999-2008
11-((1-(3-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine  0   *Aporphines *Piperazines Ligands Receptors, Dopamine D3. Bioorg Med Chem 2011 Mar 15;19(6):1999-2008
PF 592379  0   *Aminopyridines *Morpholines Receptors, Dopamine D3/agonists. Xenobiotica 2010 Nov;40(11):730-42
1H-indole-2-carboxylic acid (4-(2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl)cyclohexyl)amide  0   *Indoles *Isoquinolines Receptors, Dopamine D2/antagonists & inhibitors Receptors, Dopamine D3/antagonists & inhibitors. Mol Pharmacol 2010 Nov;78(5):925-34
2,3-di-tert-butyl-6-(4-(3-(4,5-dimethyl-4H-(1,2,4)triazol-3-ylsulfanyl)propyl)piperazin-1-yl)pyrimidine  0   *Piperazines *Pyrimidines Receptors, Dopamine D3/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Nov;335(2):506-15
N-(4-(4-((2.2)paracyclophan-4-yl)piperazin-1-yl)butyl)benzo(b)thiophenyl-2-carboxamide  0   *Piperazines *Thiophenes Ligands Receptors, Dopamine D3. J Med Chem 2010 Oct 14;53(19):7219-28
N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo(d)thiazole-2,6-diamine  0   *Biphenyl Compounds *Piperazines *Thiazoles Receptors, Dopamine D3/agonists. J Neurosci Res. 2010 Aug 15;88(11):2513-23
N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamide  0   *Indoles *Piperazines Receptors, Dopamine D3/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2559-70
N-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amide  0   *Pyridines *Sulfonamides Receptors, Dopamine D3/antagonists & inhibitors. Naunyn Schmiedebergs Arch Pharmacol 2008 Nov;378(5):515-28
N(6)-(2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo(d)thiazole-2,6-diamine  0   *Piperazines *Benzothiazoles Receptors, Dopamine D3/agonists. J Med Chem 2008 May 22;51(10):3005-19
6-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol  0   *Naphthols *Piperazines Receptors, Dopamine D3/agonists. J Med Chem 2008 Jan 10;51(1):101-17
N-(4-(2-(8-cyano-1,3a,4,9b-tetrahydro(1)benzopyrano(3,4-c)pyrrol-2(3H)-yl)ethyl)phenyl)acetamide  0   *Acetanilides *Benzopyrans Receptors, Dopamine D3/antagonists & inhibitors. J Pharmacol Exp Ther 2008 Feb;324(2):587-99
7-(1,3-dimethyl-1H-pyrazol-5-yl)-3-(3-((4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl)thio)propyl)-2,3,4,5-tetrahydro-1H-3-benzazepine  0   *Benzazepines *Triazoles Receptors, Dopamine D3/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5076-89
Drd3 protein, rat  0   *Receptors, Dopamine D3.
Drd3 protein, mouse  0   *Receptors, Dopamine D3.
DRD3 protein, human  0   *Receptors, Dopamine D3.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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