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Complement C1 Inhibitor Protein

More information in Books or onNLM PubMed
Definition: An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II.  do not confuse with COMPLEMENT C1 INACTIVATOR PROTEINS   
Pharmacological Action Complement Inactivating Agents 		Other names Serpin G1; G1, Serpin; Esterase Inhibitor, C1; C1 Inhibitor Protein; C1 INH Protein; Plasma Protease C1 Inhibitor; Complement C1-Inhibitor Protein; C1-Inhibitor Protein; C1-INH Protein; C1 Esterase Inhibitor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
conestat alpha  0   *Complement C1 Inhibitor Protein Recombinant Proteins Angioedemas, Hereditary/drug therapy. Rev Prat. 2011 Nov;61(9 Suppl):S5-6
Serping1 protein, mouse  0   *Complement C1 Inhibitor Protein. Immunol Lett 2003 Oct 31;89(2-3);155-60

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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