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Cyclin-Dependent Kinase Inhibitor Proteins

More information in Books or onNLM PubMed
Definition: A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION.     
Pharmacological Action Protein Kinase Inhibitors
Examples Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p19; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase Inhibitor p57 		Other names Inhibitors of Cyclin Dependent Kinase 4 Proteins; Inhibitor Proteins, Cyclin-Kinase; INK4 Cyclin Dependent Kinase Inhibitors; Cyclin Kinase Inhibitor Proteins; Cyclin Dependent Kinase Inhibitor Proteins; CKI Proteins, INK4; CKI Proteins, CIP-KIP; CIP KIP Cyclin Dependent Kinase Inhibitors; CIP KIP CKI Proteins; CIP KIP CDKI Proteins; CDKI Proteins, INK4; CDKI Proteins, CIP-KIP; Inhibitors of Cyclin-Dependent Kinase 4 Proteins; INK4 CKI Proteins; INK4 CDKI Proteins; Cyclin-Kinase Inhibitor Proteins; CKI Proteins; CIP-KIP CKI Proteins; CIP-KIP CDKI Proteins; CDKI Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Kip-related protein 4, Arabidopsis  0   *Arabidopsis Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. BMB Rep. 2010 Apr;43(4):273-8
Cdkn3 protein, mouse  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Cyclin-Dependent Kinase Inhibitor Proteins. FASEB J 2006 Jan;20(1):43-9
p17Xic3 protein, Xenopus  0   *Xenopus Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Gene 2004 Nov 10;342(1):41-7
p16Xic2 protein, Xenopus  0   *Xenopus Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Gene 2004 Nov 10;342(1):41-7
KIP protein, Oryzias latipes  0   *Nuclear Proteins *Fish Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Dev Dyn 2001 Nov;222(3):439-49
cki-2 protein, C elegans  0   *Caenorhabditis elegans Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Nat Cell Biol 1999 Dec;1(8):486-92
cki-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Development 1998 Sep;135918):3585-97
ICK1 protein, Arabidopsis  0   *Arabidopsis Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Plant J 1998 Aug;15(4):501-10
SPL2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Genetics 1998 Jan;148(1):33-47
CdkI-p30 protein, Cricetulus griseus  0   *Microtubule-Associated Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Somat Cell Mol Genet 1997 Mar;23(2):147-51
SIC1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Cell 1987;50(6):927; Mol Cell Biol 1994 May;14(5):3320-8
CDKN3 protein, human  EC 3.1.3.48   *Cyclin-Dependent Kinase Inhibitor Proteins *Dual-Specificity Phosphatases. Cell 1993 Nov 19;75(4):791-803; J Neurochem 2004 Jun;89(5):1252-9
FAR1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Cyclin-Dependent Kinase Inhibitor Proteins. Cell 1993 May 21;73(4):747-60

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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