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STAT3 Transcription Factor

More information in Books or onNLM PubMed
Definition: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.      Other names Transcription Factor, Stat3beta; Transcription Factor, Stat3alpha; Transcription Factor, STAT3b; Transcription Factor, STAT3a; Transcription Factor, STAT3; Transcription Factor, APRF; Response Factor, Acute-Phase; LIF Response Factor; IL6 Response Factor; Acute Phase Response Factor; Stat3beta Transcription Factor; Stat3alpha Transcription Factor; Signal Transducer and Activator of Transcription 3; STAT3b Transcription Factor; STAT3a Transcription Factor; STAT3 Protein; LIF-Response Factor; IL6-Response Factor; Acute-Phase Response Factor; APRF Transcription Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
STX-0119  0   *Oxadiazoles *Quinolines STAT3 Transcription Factor/antagonists & inhibitors. Int J Oncol. 2011 May;38(5):1245-52
FLLL 32  0   Curcumin/*analogs & derivatives STAT3 Transcription Factor/antagonists & inhibitors. Cancer Res 2010 Mar 15;70(6):2445-54
FLLL 31  0   Curcumin/*analogs & derivatives STAT3 Transcription Factor/antagonists & inhibitors. Cancer Res 2010 Mar 15;70(6):2445-54
acetyl-phosphotyrosyl-leucyl-prolyl-glutaminyl-threonyl-valinamide  0   *Phosphopeptides Peptide Fragments STAT3 Transcription Factor/antagonists & inhibitors. Bioorg Med Chem Lett 2003 Feb 24;13(4):633-6
4-phosphoryloxycinnamate-5-amino-1,2,4,5,6,7-hexahydro-4-oxo-azepino(3,2,1-hi)indole-2-carboxylic acid-glutamine N-butyl amide  0   *Dipeptides STAT3 Transcription Factor/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2429-42
LLL-3 compound  0   *Anthraquinones STAT3 Transcription Factor/antagonists & inhibitors. Br J Cancer 2009 Jan 13;100(1):106-12
SD 1029  0   *Xanthenes STAT3 Transcription Factor/antagonists & inhibitors. Clin Cancer Res 2006 Nov 15;12(22):6844-52
stat3 protein, zebrafish  0   *Zebrafish Proteins *STAT3 Transcription Factor.
Stat3 protein, rat  0   *STAT3 Transcription Factor.
Stat3 protein, mouse  0   *STAT3 Transcription Factor.
STAT3 protein, human  0   *STAT3 Transcription Factor.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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