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1-Pyrroline-5-Carboxylate Dehydrogenase

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Definition: An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the enzyme are the cause of hyperprolinemia II.      Other names NADP+ Specific 8 Glutamate Semialdehyde Dehydrogen; Glutamyl Gamma Semialdehyde Dehydrogenase; Glutamic Gamma Semialdehyde Dehydrogenase; Dehydrogenase, Glutamyl-Gamma-Semialdehyde; Dehydrogenase, Glutamic-Gamma-Semialdehyde; Dehydrogenase, GGS; Dehydrogenase, 1-Pyrroline-5-Carboxylate; 1 Pyrroline 5 Carboxylate Dehydrogenase; NADP+ Specific 8-Glutamate Semialdehyde Dehydrogen; Glutamyl-Gamma-Semialdehyde Dehydrogenase; Glutamic-Gamma-Semialdehyde Dehydrogenase; GGS Dehydrogenase; Delta(1)-Pyrroline-5-Carboxylate Dehydrogenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
P5CDH protein, Arabidopsis  EC 1.5.1.12   *Arabidopsis Proteins *1-Pyrroline-5-Carboxylate Dehydrogenase. Cell 2005 Dec 29;123(7):1279-91
PUT2 protein, S cerevisiae  EC 1.5.1.12   *Saccharomyces cerevisiae Proteins *1-Pyrroline-5-Carboxylate Dehydrogenase.
ALDH4A1 protein, human  EC 1.5.1.12   *1-Pyrroline-5-Carboxylate Dehydrogenase.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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