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Betaine-Homocysteine S-Methyltransferase

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Definition: A ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to produce dimethylglycine and METHIONINE, respectively. This enzyme is a member of a family of ZINC-dependent METHYLTRANSFERASES that use THIOLS or selenols as methyl acceptors.      Other names S-Methyltransferase, Betaine-Homocysteine; Methyltransferase-2, Betaine-Homocysteine; Methyltransferase, Betaine-Homocysteine; Methyltransferase, Betaine Homocysteine; Methyltransferase 2, Betaine-Homocysteine; MTase, Bet-HCys; Homocysteine Methyltransferase, Betaine; Betaine Homocysteine S Methyltransferase; Betaine Homocysteine Methyltransferase 2; Bet HCys MTase; Betaine-Homocysteine Methyltransferase-2; Betaine-Homocysteine Methyltransferase 2; Betaine-Homocysteine Methyltransferase; Betaine Homocysteine Methyltransferase; Bet-HCys MTase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-(3-amino-3-carboxypropylthio)-3,3-dimethylpentanoic acid  0   *Pentanoic Acids Homocysteine/*analogs & derivatives Betaine-Homocysteine S-Methyltransferase/antagonists & inhibitors. J Med Chem 2009 Jun 25;52(12):3652-65
5-(3-amino-3-carboxypropylthio)-3-methylpentanoic acid  0   *Pentanoic Acids Homocysteine/*analogs & derivatives Betaine-Homocysteine S-Methyltransferase/antagonists & inhibitors. J Med Chem 2009 Jun 25;52(12):3652-65
2-amino-4-(2-carboxymethylsulfanylethylsulfanyl)butyric acid  0   *Butyric Acids *Sulfides Betaine-Homocysteine S-Methyltransferase/antagonists & inhibitors. J Med Chem 2006 Jun 29;49(13):3982-9
6-(3-amino-3-carboxypropylsulfanyl)hexanoic acid  0   *Hexanoic Acids *Sulfides Betaine-Homocysteine S-Methyltransferase/antagonists & inhibitors. J Med Chem 2006 Jun 29;49(13):3982-9
5-(3-amino-3-carboxypropylsulfanyl)pentanoic acid  0   *Pentanoic Acids *Sulfides Betaine-Homocysteine S-Methyltransferase/antagonists & inhibitors. J Med Chem 2006 Jun 29;49(13):3982-9
Bhmt2 protein, mouse  0   *Betaine-Homocysteine S-Methyltransferase.
BHMT2 protein, human  0   *Betaine-Homocysteine S-Methyltransferase.
Bhmt protein, rat  EC 2.1.1.5   *Betaine-Homocysteine S-Methyltransferase.
Bhmt protein, mouse  EC 2.1.1.5   *Betaine-Homocysteine S-Methyltransferase.
BHMT protein, human  EC 2.1.1.5   *Betaine-Homocysteine S-Methyltransferase.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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