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Inhibitor of Apoptosis Proteins

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Definition: A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.  APOPTOSIS REGULATORY PROTEINS is also available   
Examples Neuronal Apoptosis-Inhibitory Protein; X-Linked Inhibitor of Apoptosis Protein 		Other names Inhibitor Of Apoptosis Protein; Apoptosis Proteins Inhibitor; cIAP1 Protein; c-IAP2 Protein; Inhibitor-Of-Apoptosis Protein; Inhibitor of Apoptosis 2 Protein; Inhibitor of Apoptosis 1 Protein; c-IAP1 Protein; IAP2 Protein; IAP Protein (Apoptosis); Baculoviral Inhibitor Of Apoptosis Repeat Proteins; IAP1 Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Survivin protein, Drosophila  0   *Drosophila Proteins *Inhibitor of Apoptosis Proteins. Mol Biol Cell. 2011 Oct;22(20):3779-90
6-(2-(methylamino)propanamido)-5-oxo-9-(2-phenylacetamido)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)decahydropyrrolo(1,2-a)azocine-3-carboxamide  0   *Bicyclo Compounds, Heterocyclic Alanine/*analogs & derivatives Inhibitor of Apoptosis Proteins/antagonists & inhibitors X-Linked Inhibitor of Apoptosis Protein/antagonists & inhibitors. J Med Chem 2010 Sep 9;53(17):6361-7
survivin 1 protein, zebrafish  0   *Zebrafish Proteins *Inhibitor of Apoptosis Proteins. BMC Dev Biol 2009;9:25
SH-130  0   *Oligopeptides Inhibitor of Apoptosis Proteins. Clin Cancer Res 2008 Dec 1;14(23):7701-10
Birc4 protein, rat  0   *Inhibitor of Apoptosis Proteins.
Birc3 protein, rat  0   *Inhibitor of Apoptosis Proteins.
Birc3 protein, mouse  0   *Inhibitor of Apoptosis Proteins.
Birc2 protein, mouse  0   *Inhibitor of Apoptosis Proteins.
BIRC2 protein, human  0   *Inhibitor of Apoptosis Proteins.
BIRC3 protein, human  0   *Inhibitor of Apoptosis Proteins.
BIRC6 protein, mouse  0   *Inhibitor of Apoptosis Proteins. Nat Cell Biol 2004 Sep;6(9):804-6
inhibitor of apoptosis 1 protein, Aedes triseriatus  0   *Insect Proteins *Inhibitor of Apoptosis Proteins Zinc Fingers. Insect Mol Biol 2002 Oct;11(5):431-42
BIRC8 protein, human  0   *Inhibitor of Apoptosis Proteins Apoptosis Caspases/antagonists & inhibitors. Mol Cell Biol 2001 Jul;21(13):4292-301
BIRC7 protein, human  0   *Neoplasm Proteins *Adaptor Proteins, Signal Transducing *Inhibitor of Apoptosis Proteins Zinc Fingers Apoptosis. Curr Biol 2000 Nov 2;10(21):1359-66
DIABLO protein, human  0   *Mitochondrial Proteins *Intracellular Signaling Peptides and Proteins Apoptosis Inhibitor of Apoptosis Proteins. Cell 2000 Jul 7;102(1):43-53
BIRC6 protein, human  0   *Inhibitor of Apoptosis Proteins Neoplasm Proteins. Biochem Biophys Res Commun 1999 Nov 2;264(3):847-54
Birc5 protein, mouse  0   *Repressor Proteins *Inhibitor of Apoptosis Proteins. Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1457-62
DIAP2 protein, Drosophila  0   *Drosophila Proteins *Inhibitor of Apoptosis Proteins Zinc Fingers Apoptosis. Cell 1995 Dec 29;83(7):1253-62
thread protein, Drosophila  0   *Drosophila Proteins *Inhibitor of Apoptosis Proteins Zinc Fingers Apoptosis. Cell 1995 Dec 29;83(7):1253-62
Birc4 protein, mouse  0   *Inhibitor of Apoptosis Proteins Zinc Fingers Apoptosis. Genomics 1997 Jun 15;42(3):514-8
BIRC5 protein, human  0   *Inhibitor of Apoptosis Proteins Neoplasm Proteins Biological Markers Apoptosis Regulatory Proteins.
Pharma Action Cysteine Proteinase Inhibitors 		Nat Med 1997 Aug;3(8):917-21
inhibitor of apoptosis, Nucleopolyhedrovirus  0   *Viral Proteins *Inhibitor of Apoptosis Proteins Apoptosis Nucleopolyhedrovirus.
Pharma Action Cysteine Proteinase Inhibitors 		J Virol 1994 Apr;68(4):2521-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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