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Proto-Oncogene Proteins c-akt

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Definition: A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.      Other names Akt-beta Protein; Akt-alpha Protein; AKT3 Protein Kinase; AKT2 Protein Kinase; AKT1 Protein Kinase; c-akt3, Proto-Oncogene Proteins; c-akt2, Proto-Oncogene Proteins; c-akt1, Proto-Oncogene Proteins; c-akt, Proto-Oncogene Proteins; c akt Proto Oncogene Protein; alpha Protein, Rac-PK; akt Proto Oncogene Protein; Related to A and C Protein; Rac PK beta Protein; Rac PK alpha Protein; RAC, Proto-Oncogene Protein; RAC PK Protein; Proto-Oncogene Protein, c-akt; Proto-Oncogene Protein, akt; Proto Oncogene Proteins c akt3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ISC-4 compound  0   *Organoselenium Compounds Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Clin Cancer Res. 2011 Jul 1;17(13):4474-83
4-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-amine  0   *Pyrimidines *Pyrroles Proto-Oncogene Proteins c-akt/antagonists & inhibitors. J Med Chem 2008 Apr 10;51(7):2147-57
1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one oxime  0   *Oximes *Diarylheptanoids Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Am J Chin Med 2010;38)6):1207-22
4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide  0   *Sulfonamides *Thiadiazoles Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Mol Cancer Ther 2010 Mar;9(3):706-17
NSC 177223  0   *Nucleosides Proto-Oncogene Proteins c-akt/antagonists & inhibitors. J Biol Chem 2010 Mar 12/285(11):8383-94
5-pyrrolopyridinyl-2-thiophenecarboxamide  0   *Thienopyridines Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2244-8
CTMP protein, rat  0   *Carrier Proteins Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Nat Neurosci 2009 May;12(5):618-26
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one  0   *Benzimidazoles *Quinoxalines Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Bioorg Med Chem 2008 Sep 1;16(17):7888-93
1-(5-(3-methyl-1H-pyrazolo(3,4-c)pyridin-5-yl)pyridin-3-yloxy)-3-(3-(trifluoromethyl)phenyl)propan-2-amine  0   *Pyrazoles *Pyridines Proto-Oncogene Proteins c-akt/antagonists & inhibitors. J Med Chem 2007 Jun 28;50(13):2990-3003
Trb1 protein, mouse  EC 2.7.1.37   *Protein-Serine-Threonine Kinases CCAAT-Enhancer-Binding Protein-beta/antagonists & inhibitors Proto-Oncogene Proteins c-akt/antagonists & inhibitors. J Biol Chem 2007 Aug 17;282(33):23759-65
5-methyl-4-phenyl-1H-pyrazole  0   *Pyrazoles Proto-Oncogene Proteins c-akt/antagonists & inhibitors. J Med Chem 2007 May 17;50(10):2293-6
Akt1 protein, mouse  EC 2.7.11.1   *Proto-Oncogene Proteins c-akt. Oncogene 1993 Mar;8(3):745-54
Akt2 protein, rat  EC 2.7.1.37   *Proto-Oncogene Proteins c-akt.
Akt2 protein, mouse  EC 2.7.11.1   *Proto-Oncogene Proteins c-akt.
AKT2 protein, human  EC 2.7.1.37   *Proto-Oncogene Proteins c-akt.
Akt1 protein, rat  EC 2.7.1.37   *Proto-Oncogene Proteins c-akt.
AKT1 protein, human  EC 2.7.1.37   *Proto-Oncogene Proteins c-akt.
Akt1 protein, Drosophila  0   *Drosophila Proteins *Proto-Oncogene Proteins c-akt.
akt-2 protein, C elegans  EC 2.7.1.37   *Caenorhabditis elegans Proteins *Proto-Oncogene Proteins c-akt.
akt-1 protein, C elegans  EC 2.7.1.37   *Caenorhabditis elegans Proteins *Proto-Oncogene Proteins c-akt.
AKT3 protein, human  EC 2.7.1.-   *Proto-Oncogene Proteins c-akt.
Akt3 protein, mouse  EC 2.7.1.-   *Proto-Oncogene Proteins c-akt.
Akt3 protein, rat  EC 2.7.1.-   *Proto-Oncogene Proteins c-akt. J Biol Chem 1998 Mar 27;273(13):7201-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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