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PTEN Phosphohydrolase

More information in Books or onNLM PubMed
Definition: A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.      Other names Phosphohydrolase, PTEN; Phosphatase, PTEN; Phosphatase and Tensin Homologue on Chromosome Ten; PTEN Protein; PTEN Phosphatase; Mutated In Multiple Advanced Cancers 1 Protein; MMAC1 Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TAT-PTEN fusion protein  0   *PTEN Phosphohydrolase *tat Gene Products, Human Immunodeficiency Virus Recombinant Fusion Proteins. J Immunol 2007 Dec 15;179(12):8105-11
PTEN protein, human  EC 3.1.3.48   *PTEN Phosphohydrolase Tumor Suppressor Proteins.
Ptpmt1 protein, mouse  EC 3.1.3.-   *PTEN Phosphohydrolase. J Biol Chem 2004 Sep 10;279(37):38590-6
Pten protein, mouse  EC 3.1.3.48   *PTEN Phosphohydrolase. J Clin Invest 2004 Jun;113(12);1774-83
Pten protein, rat  EC 3.1.3.48   *PTEN Phosphohydrolase. Circulation 2004 Mar 16;109(10):1299-306
PTEN protein, Drosophila  EC 3.1.3.67   *Drosophila Proteins *PTEN Phosphohydrolase. FEBS Lett 2004 May 7;565(1-3):43-7
PTEN1 protein, Arabidopsis  EC 3.1.3.67   *Arabidopsis Proteins *PTEN Phosphohydrolase. Plant Cell 2002 Oct;14(10):2495-507
TPTE protein, human  EC 3.1.3.48   *Membrane Proteins *PTEN Phosphohydrolase. Hum Genet 2001 Dec;109(6):569-75; J Biol Chem 2001 Jun 15;276(24):21745-53
Pten protein, pufferfish  EC 3.1.3.67   *Fish Proteins *PTEN Phosphohydrolase. Oncogene 2001 Sep 6;20(39):5554-61

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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