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Receptor, Fibroblast Growth Factor, Type 1

More information in Books or onNLM PubMed
Definition: A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.     
See Also Kallmann Syndrome 		Other names fms Like Tyrosine Kinase 2; fms-Like Tyrosine Kinase-2; Fibroblast Growth Factor Soluble Receptor 1; FGFR1 Tyrosine Kinase; FGFR1 Protein; Fibroblast Growth Factor Receptor 1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea  0   *Phenylurea Compounds *Pyrimidines Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. J Med Chem. 2011 Oct 27;54(20):7066-83.
NP 603  0   *Indoles *Propionic Acids Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. Bioorg Med Chem Lett 2007 Sep 1;17(17):4812-8
ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate  0   *Acenaphthenes *Pyrroles Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. J Med Chem 2011 Jun 9;54(11):3732-45
FP-1039  0   *Immunoglobulin G *Oncogene Proteins, Fusion *Receptor, Fibroblast Growth Factor, Type 1. Nat Rev Drug Discov. 2011 May;10(5):328
1-(2-chloro-4-((5-methyl-5H-pyrrolo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. Bioorg Med Chem 2010 Oct 15;18(20):7150-63
Fgfr1 protein, rat  EC 2.7.1.112   *Receptor, Fibroblast Growth Factor, Type 1.
Fgfr1 protein, mouse  EC 2.7.1.112   *Receptor, Fibroblast Growth Factor, Type 1.
FGFR1 protein, human  EC 2.7.10.1   *Receptor, Fibroblast Growth Factor, Type 1.
CEP110-FGFR1 fusion protein, human  EC 2.7.11.-   *Oncogene Proteins, Fusion *Receptor, Fibroblast Growth Factor, Type 1 Leucine Zippers. Blood 2000 Mar 1;95(5):1788-96
FGFR1 protein, Strongylocentrotus purpuratus  EC 2.7.1.112   *Receptor, Fibroblast Growth Factor, Type 1. J Biol Chem 1996 Aug 16;271(33):20119-25

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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