Definition: A cytochrome P-450 monooxygenase that is involved in an NADPH-dependent electron transport pathway by oxidizing a variety of structurally unrelated compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Other names P450 3A, Cytochrome; P-450IIIA, Cytochrome; P-450 CYP3A, Cytochrome; N-Demethylase, Erythromycin; Erythromycin N Demethylase; Cytochrome P 450IIIA; Cytochrome P 450 CYP3A; Erythromycin N-Demethylase; Cytochrome P450 3A; Cytochrome P-450IIIA; CYP3A
