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Cyclooxygenase 2

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Definition: An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.      Other names PTGS2; Synthase, COX-2 Prostaglandin; Prostaglandin Synthase, COX-2; Prostaglandin H Synthase 2; Cyclo Oxygenase II; COX 2 Prostaglandin Synthase; Prostaglandin H Synthase-2; Cyclooxygenase-2; Cyclo-Oxygenase II; COX-2 Prostaglandin Synthase; PGHS-2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-acetoxy-7-hydroxyroyleanone  0   *Diterpenes, Abietane Cyclooxygenase Inhibitors Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. J Agric Food Chem. 2011 Oct 26;59(20):11211-8.
4-((2'-O-acetylrhamnosyloxy)benzyl)isothiocyanate  0   *Isothiocyanates Rhamnose/*analogs & derivatives Cyclooxygenase Inhibitors Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Nutr Cancer. 2011;63(6):971-82.
3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno(1,2-c)isoquinoline  0   *Indenes *Isoquinolines Cyclooxygenase Inhibitors Cyclooxygenase 2. Cancer Prev Res (Phila) 2011 Apr;4(4):592-607
SC 791  0   *Isoxazoles *Sulfonamides Cyclooxygenase 2. J Pharmacol Exp Ther 2003 Mar;304(3):959-67
robenacoxib  0   *Phenylacetates Diphenylamine/*analogs & derivatives Cyclooxygenase 2. J Vet Pharmacol Ther 2009 Feb;32(1):1-17
3-(4-bromophenyl)-6-nitrobenzo(1.3.2)dithiazolium ylide 1,1-dioxide  0   *Cyclic S-Oxides *Benzothiazoles Cyclooxygenase 2. Bioorg Med Chem. 2010 Jan 15;18(2):597-604
KO 202125  0   *Isoindoles Cyclooxygenase 2. Eur J Cancer Prev 2010 Jan;19(1):23-30
2-(4-aminophenyl)-3-(3,5-dihydroxylphenyl)propenoic acid  0   *Aniline Compounds *Caffeic Acids Arachidonate 5-Lipoxygenase/antagonists & inhibitors Cyclooxygenase 1 Cyclooxygenase 2. Basic Clin Pharmacol Toxicol 2009 Nov;105(5):350-6
6-(2,3,4-trifluorophenyl)amino-5,8-quinolinedione  0   *Quinolones Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Br J Pharmacol 2009 Jan;156(2):328-37
6-(4-fluorophenyl)amino-5,8-quinolinedione  0   *Quinolones Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Br J Pharmacol 2009 Jan;156(2):328-37
5-methoxy-8-(2-hydroxy-3-butoxy-3-methylbutyloxy)psoralen  0   *Psoralens Cyclooxygenase 2. Arch Pharm Res 2008 May;31(5):617-21
ethyl 2-methyl-5-(4-(methylsulfonyl)phenyl)-1-(3-fluorophenyl)-1H-pyrrol-3-acetate  0   *Acetates *Pyrroles Cyclooxygenase 2. J Med Chem 2007 Nov 1;50(22):5403-11
PC 406  0   *Pyrazoles *Sulfonamides Cyclooxygenase 2. Acta Pharmacol Sin 2005 Dec;26(12):1505-11
6-(1-propoxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinone S-64  0   *Hydroxylamines *Naphthoquinones Cyclooxygenase 2. Ann N Y Acad Sci 2007;1095:7-18
taiwaniaflavone  0   *Flavones Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2004 Jun;52(6):762-3
4-(2-fluoro-4-methanesulfonylphenyl)-3-(4-fluorophenyl)-5H-furan-2-one  0   *Sulfones 4-Butyrolactone/*analogs & derivatives Cyclooxygenase 2. Biomed Chromatogr 2006 Dec;20(12):1289-94
acrovestenol  0   *Acetophenones Cyclooxygenase 2. Chem Biodivers 2005 Apr;2(4):463-9
1-(2,4-dihydroxy-6-methoxy-3,5-bis(3-methylbut-2-en-1-yl)phenyl)ethanone  0   *Acetophenones Cyclooxygenase 2. Chem Biodivers 2005 Apr;2(4):463-9
2-hydroxymethyl-4-(5-(4-methoxyphenyl)-3-trifluoromethylpyrazol-1-yl)-N-propionylbenzenesulfonamide  0   *Benzothiazoles Cyclooxygenase 2. Bioorg Med Chem 2006 Dec 15;14(24):8626-34
PTGS2 protein, human  EC 1.14.99.1   *Cyclooxygenase 2.
Ptgs2 protein, rat  EC 1.14.99.1   *Cyclooxygenase 2.
peonidin  134-01-0   *Anthocyanins Cyclooxygenase 2. Phytochem Anal 2002 Nov-Dec;13(6):354-7
Ptgs2 protein, mouse  EC 1.14.99.-   *Cyclooxygenase 2. Cell Growth Differ 1992 Jul;3(7):443-50

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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