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Proto-Oncogene Proteins c-bcr

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Definition: Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.      Other names c-bcr, Proto-Oncogene Proteins; c-bcr, Proto-Oncogene Protein; c bcr Proto Oncogene Proteins; c bcr Proteins; bcr Proto Oncogene Proteins; Proto-Oncogene Proteins, c-bcr; Proto-Oncogene Proteins, bcr; Proto Oncogene Proteins c bcr; Proto Oncogene Protein c bcr; Proto Oncogene Protein bcr; Proteins, c-bcr; c-bcr Proto-Oncogene Proteins; Proto-Oncogene Protein c-bcr; Proto-Oncogene Protein bcr; Breakpoint Cluster Region Protein; c-bcr Proteins; bcr Proto-Oncogene Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Bcr protein, mouse  EC 2.7.1.37   *Proto-Oncogene Proteins c-bcr.
BCR protein, human  EC 2.7.1.37   *Proto-Oncogene Proteins c-bcr.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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