Receptors (definition)

encyclopedia of medical concepts

ψ ψ	Receptors, Notch

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Definition: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.

Examples Receptor, Notch1; Receptor, Notch2

Other names Notch Proteins; Notch Receptors

Substance	CAS Registry & name	Categories	Source
Notch4 protein, rat	0	*Receptors, Notch.	Microvasc Res 2000 Sep;60(2):91-103
notch protein, Xenopus	0	*Receptors, Notch.	Dev Biol 2010 Mar 15;339(2):477-92
Notch3 protein, zebrafish	0	Zebrafish Proteins Receptors, Notch.	Development 2007 Mar;134(6):1111-22
NOTCH3 protein, human	0	*Receptors, Notch.
Notch3 protein, mouse	0	*Receptors, Notch.
Notch3 protein, rat	0	*Receptors, Notch Calcium-Binding Proteins.	FASEB J 2004 Sep;18(12):1421-3
notch protein, Drosophila	0	Drosophila Proteins Receptors, Notch.
NOTCH4 protein, human	0	Proto-Oncogene Proteins Receptors, Notch Major Histocompatibility Complex.	Gene 1997 Apr 21;189(2):235-44
Notch4 protein, mouse	146991-60-8	Proto-Oncogene Proteins Receptors, Notch.	J Virol 1992 Apr;66(4):2594-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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Receptors, Notch