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Benzodioxoles

More information in Books or onNLM PubMed
Definition: Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.     
Examples Piperonyl Butoxide; Safrole 		Other names 1,3 Dioxindans; 1,3 Dioxaindans; 1,3-Dioxindans; 1,3-Dioxaindans; Methylenedioxybenzenes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-allyl-1,3-benzodioxol  0   *Allyl Compounds *Benzodioxoles Enzyme Activators. Clin Cancer Res. 2011 Dec 1;17(23):7265-72.
daurinol  0   *Naphthalenes *Benzodioxoles. Neoplasia. 2011 Nov;13(11):1043-57.
KX2 328  0   *Quinazolines *Benzodioxoles src-Family Kinases/antagonists & inhibitors. Neurosci Res. 2011 Dec;71(4):348-54.
5-methyl-benzo(1,3)dioxole-4,7-dione  0   *Benzodioxoles. Nat Prod Res. 2011 Sep;25(16):1488-96
5-methylbenzo(1,3)dioxole-4,7-diol  0   *Benzodioxoles. Nat Prod Res. 2011 Sep;25(16):1488-96
ivory wave  0   *Lidocaine *Pyrrolidines *Benzodioxoles Drug Combinations Street Drugs. Emerg Med J. 2011 Dec;28(12):1059-60.
4-butyl-11-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-(1,3)dioxolo(4,5-c)phenanthridin-5(4H)-one  0   *Phenanthridines *Benzodioxoles. Biochem Biophys Res Commun. 2011 Dec 2;415(4):714-9.
4-butyl-11-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-7-methoxy-(1,3)dioxolo(4,5-c)phenanthridin-5(4H)-one  0   *Phenanthridines *Benzodioxoles. Biochem Biophys Res Commun. 2011 Dec 2;415(4):714-9.
VX 809  0   *Aminopyridines *Benzodioxoles. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8.
ethyl piperate  0   *Fatty Acids, Unsaturated *Benzodioxoles. Drug Metab Dispos. 2011 May;39(5):796-802.
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline  0   *Quinolines *Benzodioxoles. Neuroscience. 2010 Sep 29;170(1):54-66.
2-(3-methoxyphenyl)-6, 7-methylenedioxoquinolin-4-one  0   *Quinolones *Benzodioxoles. Hum Exp Toxicol. 2011 Aug;30(8):1045-52.
refrofractamide A  0   *Amides *Benzodioxoles Histone Deacetylase Inhibitors. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4844-6.
NSC 368262  0   *Aminopyridines *Benzodioxoles. ACS Chem Biol 2011 May 20;6(5):432-43
3-(2-(1,3-benzodioxol-5-yl)-7-methoxy-1-benzofuran-5-yl)propyl hydrogen sulfate  0   *Sulfuric Acid Esters *Benzodioxoles. Bioorg Med Chem 2011 Feb 1;19(3):1179-88
HJP 286  0   *Quinolones *Benzodioxoles Receptor, Endothelin A/antagonists & inhibitors. Am J Pathol 2010 Oct;177(4):1929-35
HJP 278  0   *Quinolones *Benzodioxoles Receptor, Endothelin A/antagonists & inhibitors. Am J Pathol 2010 Oct;177(4):1929-35
helioxanthin 8-1  0   *Phthalazines *Benzodioxoles. Antivir Chem Chemother 2010;21(2):97-103
(2S,4S)-illicinone D  0   *Benzodioxoles. Phytochemistry. 2011 Jan;72(1):115-25
N-(4'-dihydro)piperoylthiomorpholine  0   *Morpholines *Benzodioxoles. J Cardiovasc Pharmacol 2010 Sep;56(3):293-9
piperonilamine  0   *Methylamines *Benzodioxoles. Ultrason Sonochem 2011 Jan;18(1):65-7
3,4-methylenedioxypyrovalerone  0   *Pyrrolidines *Benzodioxoles Psychotropic Drugs Designer Drugs. Drug Test Anal 2010 Aug;2(8):377-82
6-((4-methoxyphenyl)(1H-imidazol-1-yl)methyl)-1,3-benzodioxol-5-ol  0   *Imidazoles *Benzodioxoles. Acta Crystallogr C. 2010 Oct;66(Pt 10):o499-502
6-((4-fluorophenyl)(1H-imidazol-1-yl)methyl)-1,3-benzodioxol-5-ol  0   *Imidazoles *Benzodioxoles. Acta Crystallogr C. 2010 Oct;66(Pt 10):o499-502
NSC 724998  0   *Isoquinolines *Benzodioxoles DNA Topoisomerases, Type I. Cancer Res 2007 Nov 1;67(21):10397-405
4-(3-(6-(3-benzo(1,3)dioxol-5-yl-5-thiophen-3-ylphenoxy)hexyl)-2-(2-carboxyethyl)phenoxy)butyric acid  0   *Phenylpropionates *Benzodioxoles Receptors, Leukotriene B4/antagonists & inhibitors. Prostaglandins Other Lipid Mediat 2010 Jun;92(1-4):33-43
4-(2'-hydroxy-3'-methylbut-3'-enyloxy)-8H-(1,3)dioxolo(4,5-h)chromen-8-one  0   *Coumarins *Benzodioxoles. Phytochemistry 2010 Feb;71(2-3):230-4
NSC 725776  0   *Isoquinolines *Benzodioxoles DNA Topoisomerases, Type I. J Pharm Biomed Anal 2010 Sep 5;52(5):714-20
NSC 743400  0   *Isoquinolines *Benzodioxoles DNA Topoisomerases, Type I. J Pharm Biomed Anal 2010 Sep 5;52(5):714-20
5-(3,4-(methylenedioxy)phenyl)-pent-2-ene piperidine  0   *Piperidines *Benzodioxoles. Molecules 2010;15(4):2398-404
aminotadalafil  0   *Carbolines *Benzodioxoles. Rapid Commun Mass Spectrom 2006;20(15):2317-27
aschantin  0   *Lignans *Benzodioxoles Nitric Oxide Synthase Type II/antagonists & inhibitors. Phytother Res. 2010 May;24(5):748-53
kobusin  0   *Lignans *Benzodioxoles Nitric Oxide Synthase Type II/antagonists & inhibitors. Phytother Res. 2010 May;24(5):748-53
(3-thienylidene)-3,4-methylenedioxybenzoylhydrazide  0   *Thiophenes *Benzodioxoles. Am J Hypertens 2010 Feb;23(2):135-41
2-benzo(1,3)dioxol-5-ylthiazole  0   *Thiazoles *Benzodioxoles. Biol Pharm Bull 2009 Aug;32(8):1364-70
worenine  0   *Quinolizines *Benzodioxoles. J Pharm Biomed Anal 2010 Jan 5;51(1):236-43
peperomin E  0   *Benzodioxoles. Bioorg Med Chem Lett 2009 Aug 1;19(15):4084-7
2,6-didehydropeperomin B  0   *Benzodioxoles. Bioorg Med Chem Lett 2009 Aug 1;19(15):4084-7
6-formyl-isoophiopogonanone A  0   *Isoflavones *Benzodioxoles. J Sep Sci 2009 Jun;32(11):1949-56
6-aldehydo-isoophiopogonone A  0   *Isoflavones *Benzodioxoles. J Sep Sci 2009 Jun;32(11):1949-56
methylophiopogonanone A  0   *Isoflavones *Benzodioxoles. J Sep Sci 2009 Jun;32(11):1949-56
CUDC 305  0   *Imidazoles *Benzodioxoles. Clin Cancer Res 2009 Jun 15;15(12):4046-57
4'-hydroxy-4-methoxy-5,6,5',6'-bis(methylenedioxy)-2-hydroxymethyl-2'-methoxycarbonylbiphenyl  0   *Benzodioxoles. Yao Xue Xue Bao 2007 Oct;42(10):1054-7
4-hydroxy-4'-methoxy-5,6,5',6'-bis(methylenedioxy)-2-hydroxymethyl-2'-methoxycarbonylbiphenyl  0   *Benzodioxoles. Yao Xue Xue Bao 2007 Oct;42(10):1054-7
5,4-didehydro-5,9,14,18-tetraaza-di(2,2-dimethyl-(5,6)benzo(1,3)dioxolo)(a,h)cyclotetradecene  0   *Aza Compounds *Benzodioxoles. Chem Biol Drug Des 2009 May;73(5):494-501
illioliganone C  0   *Benzodioxoles. J Nat Prod 2009 Jun;72(6):1017-21
illioliganone B  0   *Benzodioxoles. J Nat Prod 2009 Jun;72(6):1017-21
illioliganone A  0   *Benzodioxoles. J Nat Prod 2009 Jun;72(6):1017-21
7-(3-(1,3-benzodioxol-5-yl)propyl)-2-(2-furyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine  0   *Triazoles *Benzodioxoles. Antiviral Res 2009 Jun;82(3):141-7
UCP 0054287  0   *Benzamides *Benzodioxoles. J Pharmacol Sci 2009 Mar;109(3):463-8
6-methoxy-9-methyl-(1,3)dioxolo(4,5-h)quinolin-8(9H)-one  0   *Quinolones *Benzodioxoles Aromatase Quinone Reductases/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):1873-84
N-(6-((2-benzylidenehydrazinyl)carbonyl)-1,3-benzodioxol-5-yl)methanesulfonamide  0   *Hydrazones *Benzodioxoles. Bioorg Med Chem 2009 Feb 1;17(3):1125-31
1-aceto-3-(3-(2-(1-methoxycarboxyl-2-methoxy)-1-yl)benzyloxy)phenyl-5-(benzo-(1,3)dioxolyl)-4,5-dihydropyrazoline  0   *Pyrazoles *Benzodioxoles. J Agric Food Chem 2008 Nov 26;56(22):10767-73
machilin A  0   *Lignans *Benzodioxoles. Planta Med 2009 Feb;75(2):152-7
fargesin  0   *Lignans *Benzodioxoles. Nitric Oxide 2009 Mar;20(2):122-8
7,7'-dihydrotaiwanin C  0   *Benzofurans *Benzodioxoles. Planta Med 2008 Dec;74(15):1806-11
WLP-S-10  0   *Benzodioxoles Methionine/*analogs & derivatives. Liver Int 2008 Nov;28(9):1226-35
JZL 184  0   *Benzodioxoles *Piperidines Anti-Anxiety Agents. Nat Chem Biol 2009 Jan;5(1):37-44
N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine  0   *Imidazoles *Benzodioxoles Receptor, Anaphylatoxin C5a. J Pharmacol Exp Ther 2008 Dec;327(3):898-909
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  0   *Benzamides *Benzodioxoles. Science 2008 Sep 12;321(5895):1493-5
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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