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Glucagon-Like Peptide 1

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Definition: A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.     
Pharmacological Action Incretins 		Other names GLP-1; Glucagon Like Peptide 1; GLP 1; Glucagon-Like Peptide-1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-2-(4-fluorobenzamido)ethylmaleimide-EM 3106B  0   *Maleimides Glucagon-Like Peptide 1/*analogs & derivatives Fluorine Radioisotopes. Mol Pharm. 2011 Oct 3;8(5):1775-82.
glucagon-like peptide-1(28-36)amide  0   *Peptide Fragments *Glucagon-Like Peptide 1. Regul Pept 2011 Apr 11;167(2-3):177-84
glucagon-like peptide 1 (7-36), Val(8)  0   *Peptide Fragments *Glucagon-Like Peptide 1. Neuroscience 2010 Nov 10;170(4):1239-48
albiglutide  0   Glucagon-Like Peptide 1/*analogs & derivatives. J Clin Endocrinol Metab 2008 Dec;93(12):4810-7
BIM 51077  0   Glucagon-Like Peptide 1/*analogs & derivatives Glucagon-Like Peptide 1/agonists. Curr Opin Investig Drugs 2007 Oct;8(10):842-8
LY307161  0   Glucagon-Like Peptide 1/*analogs & derivatives. J Pharm Sci. 2005 Dec;94(12):2749-63
GLP-2 receptor  0   *Receptors, Glucagon Glucagon-Like Peptides Glucagon-Like Peptide 1.
sitagliptin  0   *Pyrazines *Triazoles Glucagon-Like Peptide 1.
Pharma Action Dipeptidyl-Peptidase IV Inhibitors 		J Med Chem 2005 Jan 13;48(1):141-51JUVISYNC; JANUVIA
glucagon-like peptide-1 (7-36)amide, N-pyroglutamyl  0   *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives Glucagon-Like Peptide 1/*analogs & derivatives. J Endocrinol 2004 Mar;180(3):379-88
glucagon-like peptide-1 (7-36)amide, N-acetyl  0   *Peptide Fragments *Glucagon-Like Peptide 1. J Endocrinol 2004 Mar;180(3):379-88
exendin (1-9), Ser(2)  0   *Peptide Fragments Glucagon-Like Peptide 1. Nat Med 2003 Sep;9(9):1173-9
(2-sulfo-9-fluorenylmethoxycarbonyl)3-exendin-4  0   *Fluorenes *Peptides Glucagon-Like Peptide 1. Biochem Biophys Res Commun 2003 May 30;305(2):386-91
1-(((3-hydroxy-1-adamantyl)amino)acetyl)-2-cyanopyrrolidine  0   *Pyrrolidines Adamantane/*analogs & derivatives Hypoglycemic Agents Glucagon-Like Peptide 1. J Med Chem 2003 Jun 19;46(13):2774-89
liraglutide  0   Glucagon-Like Peptide 1/*analogs & derivatives. Diabetes 2001 Nov;50(11):2530-9VICTOZA
exendin (5-39)  0   *Peptide Fragments Glucagon-Like Peptide 1. Brain Res 2000 Sep 29;878(1-2):194-8
glucagon-like peptide 1 (7-36)amide, Ser(8)  0   *Peptide Fragments *Glucagon-Like Peptide 1. J Endocrinol 1998 Oct;159(1):93-102
glucagon-like peptide-1 (9-36)-amide  0   *Peptides Glucagon-Like Peptide 1/*analogs & derivatives. Peptides 1998;19(5):877-82
fluorescein-Trp(25)-exendin-4  0   *Peptides *Fluoresceins Glucagon-Like Peptide 1. Peptides 1997;18(2):319-21
exendin (9-39) amide  0   *Peptide Fragments Venoms Glucagon-Like Peptide 1. Diabetes 1995 Jan;44(1):16-9
exendin (9-39)  133514-43-9 Exendin 3 (Heloderma horridum), 1-de-L-histidine-2-de-L-serine-3-de-L-aspartic acid-4-deglycine-5-de-L-threonine-6-de-L-phenylalanine-7-de-L-threonine-8-de-L-serine  *Peptide Fragments Venoms Glucagon-Like Peptide 1. Diabetes 1993 Nov;42(11):1678-82
glucagon-like peptide 1 (7-36), Ala(36)  0   *Glucagon *Peptide Fragments *Glucagon-Like Peptide 1. Electrophoresis 1993 May-Jun;14(5-6):486-91
exenatide  141732-76-5 Exendin 4  *Peptides *Venoms Lizards Venoms Glucagon-Like Peptide 1.
Pharma Action Hypoglycemic Agents 		J Biol Chem 1992 Apr 15;267(11):7402-5BYDUREON; BYETTA
exendin receptor  0   *Receptors, Gastrointestinal Hormone Glucagon-Like Peptide 1. J Biol Chem 1992 Apr 15;267(11):7102-5
exendin 3  130391-54-7 Exendin 3  *Peptides Venoms Glucagon-Like Peptide 1. J Biol Chem 1990;265(33):20259
glucagon-like peptide 1 (7-36)  107444-51-9   *Peptide Fragments *Glucagon-Like Peptide 1. Diabetes 1989;38(12):1534
glucagon-like peptide 1 (1-37)  87805-34-3   *Glucagon-Like Peptide 1. Biochem Biophys Res Commun 1988;152(3):1038
glucagon-like peptide 1 (1-36)amide  99658-04-5   *Glucagon-Like Peptide 1. J Endocrinol 1988;116(3):357
glucagon-like peptide 1 (7-36)amide  119637-73-9   *Peptide Fragments *Glucagon-Like Peptide 1. Gastroenterology 1974;67(4):748-50
glucagon-like peptide receptor  0   *Receptors, Glucagon Glucagon-Like Peptides Glucagon-Like Peptide 1. Endocrinology 1987;121(3):1076
glucagon-like peptide 1 (7-37)  106612-94-6   *Peptide Fragments *Glucagon-Like Peptide 1. J Clin Invest 1987;79(2):616
helospectin I  93438-37-0 Helospectin I  *Peptides Lizards Venoms Glucagon-Like Peptide 1. J Biol Chem 1984;259(19):11751
heliodermin  89468-62-2 Helospectin I, 5-L-isoleucine-8-L-glutamine-9-L-glutamine-24-L-alanine-30-L-arginine-34-de-L-arginine-36-L-prolinamide-37-de-L-serine-38-de-L-serine  *Peptides Phospholipases A/antagonists & inhibitors Venoms Glucagon-Like Peptide 1.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Enzyme Inhibitors 		FEBS Lett 1984;166(2):273

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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