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Nitric Oxide Synthase Type II

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Definition: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.      Other names NOS II; Nitric Oxide Synthase, Type II; Nitric Oxide Synthase II; NOS-II; Inducible Nitric Oxide Synthase; Inducible NOS Protein; INOS Enzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-hydroxy-N-(3-(trifluoromethyl)phenyl)benzamide  0   *Benzamides Nitric Oxide Synthase Type II/antagonists & inhibitors. J Clin Immunol. 2011 Dec;31(6):1131-42.
6-acetoxy-7-hydroxyroyleanone  0   *Diterpenes, Abietane Cyclooxygenase Inhibitors Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. J Agric Food Chem. 2011 Oct 26;59(20):11211-8.
4-((2'-O-acetylrhamnosyloxy)benzyl)isothiocyanate  0   *Isothiocyanates Rhamnose/*analogs & derivatives Cyclooxygenase Inhibitors Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Nutr Cancer. 2011;63(6):971-82.
W1400  0   *Amidines Nitric Oxide Synthase Type II/antagonists & inhibitors. ChemMedChem. 2011 Jul 4;6(7):1203-6
flavalin A  0   *Sesquiterpenes Nitric Oxide Synthase Type II/antagonists & inhibitors. J Nat Prod. 2011 Feb 25;74(2):169-74
kuraridin  0   *Monoterpenes *Chalcones Nitric Oxide Synthase Type II/antagonists & inhibitors. Biol Pharm Bull 2010;33(6):1019-23
4-((2-cyclobutyl-1H-imidazo(4,5-b)pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one  0   *Pyrazines *Fluoroquinolones Nitric Oxide Synthase Type II/antagonists & inhibitors Nitric Oxide Synthase Type I/antagonists & inhibitors. J Med Chem 2009 May 14;52(9):3047-62
3-(2-hydroxyphenyl)-1-(5-methylfuran-2-yl)propenone  0   *Furans *Propiophenones Nitric Oxide Synthase Type II/antagonists & inhibitors. Immunopharmacol Immunotoxicol 2010 Sep;32(3):495-506
1-(benzylamino)ethaniminium  0   *Amidines *Benzylamines Nitric Oxide Synthase Type II/antagonists & inhibitors. J Med Chem 2009 Mar 12;52(5):1481-5
aschantin  0   *Lignans *Benzodioxoles Nitric Oxide Synthase Type II/antagonists & inhibitors. Phytother Res. 2010 May;24(5):748-53
kobusin  0   *Lignans *Benzodioxoles Nitric Oxide Synthase Type II/antagonists & inhibitors. Phytother Res. 2010 May;24(5):748-53
N-(3-chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylthiazole-5-carboxamide  0   *Thiazoles *Fluoroquinolones Nitric Oxide Synthase Type II/antagonists & inhibitors. Mol Pharmacol 2009 Jul;76(1):153-62
6-(2,3,4-trifluorophenyl)amino-5,8-quinolinedione  0   *Quinolones Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Br J Pharmacol 2009 Jan;156(2):328-37
6-(4-fluorophenyl)amino-5,8-quinolinedione  0   *Quinolones Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Br J Pharmacol 2009 Jan;156(2):328-37
6-(2-fluoropropyl)-4-methylpyridin-2-amine  0   *Aminopyridines Fluorine Radioisotopes Nitric Oxide Synthase Type II/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2443-53
CR 3294  0   *Amidines Thiourea/*analogs & derivatives Nitric Oxide Synthase Type II/antagonists & inhibitors. Autophagy 2008 Nov 16;4(8):1042-53
ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate  0   *Diterpenes, Kaurane Nitric Oxide Synthase Type II/antagonists & inhibitors. Mediators Inflamm 2007;2007:93148
N(G)-amino-N(G)-2,2,2-trifluoroethylarginine  0   Arginine/*analogs & derivatives Nitric Oxide Synthase Type II/antagonists & inhibitors. J Med Chem 2008 Feb 28;51(4):924-31
cyclo(dehydrohistidyl-tryptophyl)  0   *Peptides, Cyclic Nitric Oxide Synthase Type II/antagonists & inhibitors. Biochem Pharmacol 2008 Feb 15;75(4):923-30
N-(2-(1,3-benzodioxol-5-yl)ethyl)-1-(2-(1H-imidazol-1-yl)-6-methyl-4-pyrimidinyl)-2-pyrrolidinecarboxamide  0   *Pyrimidines *Benzodioxoles Nitric Oxide Synthase Type II/antagonists & inhibitors. J Med Chem 2007 Mar 22;50(6):1146-57
taiwaniaflavone  0   *Flavones Cyclooxygenase 2 Nitric Oxide Synthase Type II/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2004 Jun;52(6):762-3
sumaflavone  0   *Flavones Nitric Oxide Synthase Type II/antagonists & inhibitors. J Ethnopharmacol 2006 Apr 21;105(1-2):107-13
5-hydroxytriptolide  0   *Diterpenes Nitric Oxide Synthase Type II/antagonists & inhibitors. J Pharmacol Exp Ther 2006 Jan;316(1):121-8
2-(2-(4-methoxypyridin-2-yl)ethyl)-3H-imidazo(4,5-b)pyridine  0   *Imidazoles *Pyridines Nitric Oxide Synthase Type II/antagonists & inhibitors. Mol Pharmacol 2006 Jan;69(1):328-37
NOS2 protein, human  EC 1.14.13.39   *Nitric Oxide Synthase Type II.
Nos2 protein, rat  EC 1.14.13.39   *Nitric Oxide Synthase Type II.
Nos2 protein, mouse  EC 1.14.13.39   *Nitric Oxide Synthase Type II.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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