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Benzophenanthridines

More information in Books or onNLM PubMed
Definition: Compounds of four rings containing a nitrogen. They are biosynthesized from reticuline via rearrangement of scoulerine. They are similar to BENZYLISOQUINOLINES. Members include chelerythrine and sanguinarine.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methyl 2'-(7,8-dihydrosanguinarine-8-yl)acetate  0   *Isoquinolines *Benzophenanthridines Alkaloids. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6960-3
N-methyl-12-ethoxy-2-hydroxy-3,8,9-trimethoxybenzo(c)phenanthridinium  0   *Benzophenanthridines. Invest New Drugs. 2011 Oct;29(5):730-41.
chelilutine  0   *Benzophenanthridines. Cell Biol Toxicol 2001;17(1):51-63
sanguilutine  0   *Benzophenanthridines. Cell Biol Toxicol 2001;17(1):51-63
lucidamine A  0   *Benzophenanthridines. J Nat Prod 2007 Oct;70(10):1650-3
dihydrochelerythrine  0   *Benzophenanthridines. J Nat Prod 2007 Oct;70(10):1650-3
fagaridine  0   *Benzophenanthridines. J Nat Prod. 1999 Jun;62(6):864-7
homochelidonine  0   *Berberine Alkaloids *Benzophenanthridines. Angew Chem Int Ed Engl. 2007;46(3):433-6
dihydrosanguinarine  0   *Isoquinolines *Benzophenanthridines. Zhongguo Zhong Yao Za Zhi 2005 Feb;30(3):195-7
12-methoxydihydrochelerythrine  0   *Benzophenanthridines. Org Biomol Chem. 2003 Sep 7;1(17):3024-32
O-(p-nitrobenzoyl)chelidonine  0   *Benzophenanthridines. Eur J Med Chem 2001 Nov-Dec;36(11-12):951-60
6-methoxydihydrosanguinarine  0   *Isoquinolines *Benzophenanthridines. Planta Med 2001 Jul;67(5):423-7
7-hydroxynitidine  0   *Benzophenanthridines. Org Lett 1999 Oct 7;1(7):985-8
NK 109  0   *Benzophenanthridines. Br J Cancer 1997;76(5):571-81
6-methylnorchelerythrine  0   *Dioxoles *Benzophenanthridines. J Nat Prod 1994 Sep;57(9):1206-11
6-methyldihydrochelerythrine  0   *Dioxoles *Benzophenanthridines. J Nat Prod 1994 Sep;57(9):1206-11
dihydronitidine  13063-06-4   *Benzophenanthridines. Sci China B 1992 Sep;35(9):1101-9
chelidonine  476-32-4   *Benzophenanthridines Berberine Alkaloids. Pol J Pharmacol Pharm 1989;41(2):125
chelirubine  18203-11-7   *Benzophenanthridines. Yakugaku Zasshi 1981;101(8):663
chelerythrine  34316-15-9 1,2-dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium  *Benzophenanthridines Protein Kinase C/antagonists & inhibitors.
Pharma Action Anti-Bacterial Agents ; Antineoplastic Agents 		Lloydia 41(2):145;1978
nitidine  6872-57-7   *Benzophenanthridines. Cancer Treat Rep 60(8):1025;1976; J Pharm Sci 66(7):986;1977
protopine  130-86-9   *Berberine Alkaloids *Benzophenanthridines.
Pharma Action Analgesics, Opioid ; Histamine H1 Antagonists ; Platelet Aggregation Inhibitors 		Kardiologiia 18(4):76;1978; Therapie 28(4):767;1973; Yakugaku Zasshi 97(1):93;1977
sanguinarine  2447-54-3   *Isoquinolines *Benzophenanthridines.
Pharma Action Anti-Infective Agents ; Cardiotonic Agents 		Am J Clin Nutr 28(8):883;1975; Biochem Pharmacol 27(21):2555;1978; Biochim Biophys Acta 511(2):251;1978; Cancer Treat Rep 60(8):1178;1976; Eur J Pharmacol 1979;60(4):373; Farm Zh 3:40;1977; J Chromatogr 132(2):359;1977; J Physiol 1979;295:1; J Trop Med Hyg 80(7):149;1977; Lloydia 41(2):145;1978
fagaronine  41758-44-5   *Alkaloids *Benzophenanthridines.
Pharma Action Antineoplastic Agents ; Antineoplastic Agents, Phytogenic 		J Org Chem 39(22):3239;1974; J Pharm Sci 61(11):1858;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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