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Caspase 2

More information in Books or onNLM PubMed
Definition: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.      Other names Procaspase 2; Pro Caspase 2; ICH 1 Protease; Procaspase-2; Pro-Caspase-2; ICH-1 Protease; Caspase-2; Caspase 2 Subunit p18; Caspase 2 Subunit p13; Caspase 2 Subunit p12
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CASP2 protein, human  EC 3.4.22.-   *Cysteine Endopeptidases *Caspase 2 Apoptosis.
Casp2 protein, mouse  EC 3.4.22.-   *Caspase 2 Apoptosis. Genes Dev 1994 Jul 15;8(14):1613-26

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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