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Caspase 8

More information in Books or onNLM PubMed
Definition: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.     
See Also Autoimmune Lymphoproliferative Syndrome 		Other names Procaspase 8; Pro Caspase 8; Procaspase-8; Pro-Caspase-8; Mch5 Protease; MACH Protein; FLICE Protein; Caspase-8; CAP4 Protease
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CASP8 protein, human  EC 3.4.22.-   *Caspase 8.
Casp8 protein, rat  EC 3.4.22.-   *Caspase 8.
Casp8 protein, mouse  EC 3.4.22.-   *Caspase 8.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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