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Receptors, Tumor Necrosis Factor, Member 14

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Definition: A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.      Other names Entry Mediator, Herpesvirus; Tumor Necrosis Factor Receptor Subfamily, Member 1; HveA Protein; HVEM Protein; Tumor Necrosis Factor Receptor Superfamily, Member; Herpesvirus Entry Mediator
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Tnfrsf14 protein, mouse  0   *Receptors, Tumor Necrosis Factor, Member 14.
TNFRSF14 protein, human  0   *Receptors, Tumor Necrosis Factor, Member 14.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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