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Tumor Necrosis Factor Decoy Receptors

More information in Books or onNLM PubMed
Definition: A subclass of tumor necrosis family receptors that lack cell signaling domains. They bind to specific TNF RECEPTOR LIGANDS and are believed to play a modulating role in the TNF signaling pathway. Some of the decoy receptors are products of distinct genes, while others are products of ALTERNATIVE SPLICING of the MRNA for the active receptor.     
Examples Osteoprotegerin; Receptors, Tumor Necrosis Factor, Member 6b; Receptors, Tumor Necrosis Factor, Member 10c 		Other names TRAIL Receptors, Decoy; Receptors, Decoy TRAIL; Receptors, Decoy FAS; FAS Receptors, Decoy; Tumor Necrosis Factor Decoy Receptor; Decoy Receptor, Tumor Necrosis Factor; Decoy Receptor for TRAIL Ligands; Decoy Receptor for FAS Ligands; Decoy TRAIL Receptors; Decoy FAS Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TNFRSF10D protein, human  0   *Tumor Necrosis Factor Decoy Receptors. J Cancer Res Clin Oncol 2002 Feb;128(2):73-9
TNFRSF10C protein, human  0   *Tumor Necrosis Factor Decoy Receptors GPI-Linked Proteins Apoptosis. J Biol Chem 1997 Oct 10;272(41):25417-20
recombinant human tumor necrosis factor-binding protein-1  0   *Receptors, Tumor Necrosis Factor, Type I *Tumor Necrosis Factor Decoy Receptors Polyethylene Glycols Recombinant Proteins. Biotherapy 1991;3(2):159; Exp Neurol 1995 Feb;131(2):221-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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