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Death Domain Receptor Signaling Adaptor Proteins

More information in Books or onNLM PubMed
Definition: Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.     
Examples CASP8 and FADD-Like Apoptosis Regulating Protein; CRADD Signaling Adaptor Protein; Edar-Associated Death Domain Protein; Fas-Associated Death Domain Protein; Receptor-Interacting Protein Serine-Threonine Kinases; TNF Receptor-Associated Death Domain Protein 		Other names fas Death Inducing Signaling Complex Components; Fas DISC Components; fas Death-Inducing Signaling Complex Components; Fas-DISC Components; Death Inducing Signaling Complex Proteins; Death Effector Domain Signaling Adaptor Proteins; DISC (Death Inducing Signaling Complex); DED Signaling Adaptor Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DENND1A protein, human  0   *Death Domain Receptor Signaling Adaptor Proteins. J Med Genet. 2012 Feb;49(2):90-5
DENND1B protein, human  0   *Guanine Nucleotide Exchange Factors *Death Domain Receptor Signaling Adaptor Proteins. N Engl J Med. 2010 Jan 7;362(1):36-44
Madd protein, mouse  0   *Guanine Nucleotide Exchange Factors *Death Domain Receptor Signaling Adaptor Proteins.
Madd protein, rat  0   *Guanine Nucleotide Exchange Factors *Death Domain Receptor Signaling Adaptor Proteins.
Dedd protein, mouse  0   *Death Domain Receptor Signaling Adaptor Proteins Apoptosis.
PIDD protein, human  0   *Death Domain Receptor Signaling Adaptor Proteins.
DEDD2 protein, human  0   *DNA-Binding Proteins *Nuclear Proteins *Death Domain Receptor Signaling Adaptor Proteins Apoptosis. J Biol Chem 2002 Mar 1;277(9):7501-8
Lrdd protein, mouse  0   *Death Domain Receptor Signaling Adaptor Proteins. Biochim Biophys Acta 2000 May 23;1478(2):280-8; Nat Genet 2000 Sep;26(1):122-5
DEDD protein, human  0   *DNA-Binding Proteins *Death Domain Receptor Signaling Adaptor Proteins. EMBO J 1998 Oct 15;17(20):5974-86; Endocrinology 1998 Dec;139(12):4839-48
MADD protein, human  0   *Guanine Nucleotide Exchange Factors *Death Domain Receptor Signaling Adaptor Proteins. J Biol Chem 1997 May 2;272(18):12069-75

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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