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Proteinase Inhibitory Proteins, Secretory

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Definition: Peptides and proteins found in BODILY SECRETIONS and BODY FLUIDS that are PROTEASE INHIBITORS. They play a role in INFLAMMATION, tissue repair and innate immunity (IMMUNITY, INNATE) by inhibiting endogenous proteinases such as those produced by LEUKOCYTES and exogenous proteases such as those produced by invading microorganisms.     
Pharmacological Action Protease Inhibitors
See Also Protease Inhibitors
Examples Elafin; Protease Nexins; Secretory Leukocyte Peptidase Inhibitor; Serpins 		Other names Inhibitors, Neutrophil Elastase; Elastase Inhibitors, Neutrophil; Protease Inhibitory Proteins, Secretory; Protease Inhibitory Peptides, Secretory; Peptidase Inhibitory Proteins, Secretory; Peptidase Inhibitory Peptides, Secretory; Proteinase Inhibitory Peptides, Secretory; Neutrophil Elastase Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SPINK4 protein, human  0   *Proteinase Inhibitory Proteins, Secretory. J Steroid Biochem Mol Biol. 2012 Feb;128(3-5):145-53.
SPINK12 protein, mouse  0   *Proteinase Inhibitory Proteins, Secretory. Exp Dermatol. 2011 Nov;20(11):905-10.
SPINK6 protein, human  0   *Proteinase Inhibitory Proteins, Secretory. J Biol Chem 2010 Oct 15;285(42):32174-81
Spinlw1 protein, rat  0   *Proteinase Inhibitory Proteins, Secretory. Asian J Androl 2009 No0v;11(6):731-9
Spink9 protein, human  0   *Proteinase Inhibitory Proteins, Secretory Serine Proteinase Inhibitors. PLoS One 2009;4(2):e4372
serine protease inhibitor Kazal-type-like protein, mouse  0   *Proteinase Inhibitory Proteins, Secretory. Reproduction. 2008 Nov;136(5):559-71
Hai1 protein, zebrafish  0   *Zebrafish Proteins *Proteinase Inhibitory Proteins, Secretory. J Cell Sci 2007 Oct 1;120(Pt 19):3372-83
protease inhibitor 16, mouse  0   *Proteinase Inhibitory Proteins, Secretory. Circulation 2007 Oct 16;116(16):1768-75
ITIH5 protein, human  0   *Proteinase Inhibitory Proteins, Secretory Breast Neoplasms Trypsin Inhibitors. Cancer Lett 2004 Feb 10;204(1):69-77
SPINK7 protein, human  0   *Proteinase Inhibitory Proteins, Secretory.
Pharma Action Serine Proteinase Inhibitors 		Biochem Biophys Res Commun 2003 Mar 21;302(4):904-15
SPINLW1 protein, human  0   *Proteinase Inhibitory Proteins, Secretory. Gene 2001 May 30;270(1-2):93-102
SPINK5 protein, human  0   *Proteinase Inhibitory Proteins, Secretory Serine Proteinase Inhibitors. J Biol Chem 1999 Jul 30;274(31):21499-502
SPINT1 protein, human  0   *Proteinase Inhibitory Proteins, Secretory. J Biol Chem 1997 Oct 31;272(44):27558-64
ITIH4 protein, human  0   *Blood Proteins *Glycoproteins *Proteinase Inhibitory Proteins, Secretory.
Pharma Action Serine Proteinase Inhibitors 		FEBS Lett 1995 Jan 3;357(2):207-11; J Biochem (Tokyo) 1995 Jan; 117(1):14-8
alpha-thiol proteinase inhibitor  0   *Kininogens Proteinase Inhibitory Proteins, Secretory. FEBS Lett 1982;138(2):307
proteinase inhibitor II protein, plant  0   *Plant Proteins Proteinase Inhibitory Proteins, Secretory.
Pharma Action Enzyme Inhibitors 		Arch Biochem Biophys 1982;213(2):463; Plant Mol Biol 1995 Mar;27(6):1197-204
Streptomyces pepsin inhibitor  11076-29-2   *Pepstatins Pepsin A/antagonists & inhibitors Hydroxyl Radical Proteinase Inhibitory Proteins, Secretory. Biochim Biophys Acta 452(2):521;1976; J Biochem (Tokyo) 1980;87(2):573
potato proteinase inhibitor II-b  50812-33-4   *Plant Proteins Peptide Hydrolases Proteinase Inhibitory Proteins, Secretory. J Biochem (Tokyo) 74(2):335;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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